CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038083
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Myo18b 
Protein Synonyms/Alias
  
Gene Name
 Myo18b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1103RLRAAFEKKKEAGAEacetylation[1]
1322VLDPALLKKLDLTSEubiquitination[2]
1792DVRQSCQKRLRQLEMubiquitination[2]
1886QLEQSEAKCEDALKTubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2605 AA 
Protein Sequence
MAISSRLALW EQKIREEDKS PPPSSPPPLF SVIPGGFIKQ LVRETEKESK EARRRKAAAF 60
TAPEVEIPAV PTNQTNKTNN VPKPGSQQTS QDSSSTTQNS ADIPGKEPPG AGDKDSTPVT 120
STSGERPQES GPTGTPAKRT LPFKRGVRRG DVLLMVAKLD PELAKADQKV QPRDVPVDKT 180
PAPAKDSGGT KKGVTTGTSS APQPSMPEKT RTRGVGDTGQ STKGGKCQGT EGKGSRDPQT 240
IGQKEGESQS TEEQGTRSQA QEAGNKEQLG TAEKEGGGPP KKMEKEDEPK VAGAEVRPVE 300
PPVPLRKWGG FLGWRSKWDS PQSKDRVTES HRKDEKTGDL QSPAVDRSCG QLAEPTGQPS 360
GPTGQPSGPT GQLSESTGQP SGPTGQPAGP TGQPAGPTGQ PAGPTGQPAG PTGQQQEAPV 420
KMEGKVGRPQ KKLVTPRKPR ELPGVAAKTQ NPEESCKAPD RIPTTGISAE AAKRDGQPES 480
RVQGAGEPRV CTEEEVDVVK PQAEGHVESI PEVVMERLST LRPMEEKQIL QDPDRGGQSG 540
DSDQAYEDRW YEAQKVWLVQ KDGFTLATVL KPDEGTADPP AGRVRLCIDA DRTVIEVDEE 600
QVHPANPSEL DQAEDLASLV SVNESSVMNT LLQRYRAQLP YTCSGPDLIT LQPQTTTVPS 660
SGKVPRGRQD GLPAHVTSLA QRAYWALLSQ RRDQSIVALG RSGAGKTTCC EQVLEHLVGM 720
AGSVDGRVSV EKLRATFTVL RAFGCVSTGH SRRATRFAMV MSLDFNATGR VTAAQLQTVL 780
LENSRVARQP QGEGNFEVFS QLLAGMDVDL RTELNLHQMA ESSAFGMGLW SKPEDKQKAA 840
TAFSQLRGAM ELLGISEGEQ QAIWRVLAAI YHLGAAGACK VGRKQFMRFE WANHAAEALG 900
CDYEELNTAT FKHHLRQIIE QMTSGPQRQG LQDNEACSGL KMTGVECVEG MASGLYQELF 960
VAVVSLINRS FSSHHLSMAS IMVVDTPGFQ NPRHQGKDRA ATFEELCYNY AQERLQLLFY 1020
HRTFVSTLER YKEEGIPVPF DLPESSPGTT VAVVDQNPSQ VHLPAGRGAE DAGGLFWVLD 1080
EEVRVQGSSD STVLERLRAA FEKKKEAGAE EPPSMRTCEQ PLQCELFHQL GRDPVRYDLT 1140
GWLRRAKPNL AALEAPQILQ QSKREELQSL FQARAKLPPV CRAVAGLEGT SQQALHRSRV 1200
VRRAFASSLA AVKRKAPCAQ IKLQMDALIS LLRRSRLHFI HCLVPTTVES KAGQRTPSPS 1260
QPSGDQGVAN EPTALDIPAL RVQLAGSHIL EALRLHRAGY AEHMGLAQFR RRFQVLDPAL 1320
LKKLDLTSEE LDERKVVEEL LKTLDLEKKA VAVGHSQVFL KAGVVSRLER QREKLVSRNI 1380
VLFQAACRGF LSRQEYKKLK IRRLATLCIQ KNLAVFLKVK DWPWWGLLAS LRPLLSSTLG 1440
TEQLRAKEEE LTLLRQKLQK SENSRSELRQ NTDLLESKIT DLTSELADER FKGDVACQAL 1500
ESERAERLQA LREVQELKTK YQQVQDALGE VQKQLEEAQQ RIQGANLEEK PAGGADEWQM 1560
RLDCAQMEND FLRKRLQQCE ERLDSEMKAR TELEQKLGEL QSAYEEAKKM AHQLKRKCHH 1620
LTWDLEDTRV LLENQQSRNH ELEKRQKKFD LQLAQALGES MFEKSLREKV SQENNGVRWE 1680
LGQLQQQLEQ KEQEASKLKQ EVERLQGQKR ELLSCASVGD QGVASLKERV WELETNALEQ 1740
QKIHSQQENT IKQLEQLRQR FELEIERMKQ MHQKDREDQE EELEDVRQSC QKRLRQLEMQ 1800
LEQEYEEKQV ALHEKHDLEG LIGTLCDQIG HRDFDVEKRL RRDLRRTHAL LSDVQLLLAT 1860
IEDSKTSISK EELEKVHSQL EQSEAKCEDA LKTQKVLTAD LENMHSELEN VTRSKSLVDE 1920
QLYRLQFERA DLLKRIDEDQ GDLNDLMQKH KDLIAQSAAD IGQIQELQLQ LEETKKEKQK 1980
LREQLHMAQL RIQYLEQSTV ERAIVSRQEA IICDLENKTE FQKVQIKRFE VLVIRLRDSM 2040
IKMGEELSRA VKAEAQQREN SQYYQQRLEE LKAEMQELAQ REEEASRRCM ELEKYVEELA 2100
TVRQTLQTDL ETSIRRIADL QAALEEVVSS DSDTESVQTA VDCSSRSGKE GDNVSVISSQ 2160
PEGSLQSWMS CSLSLATDSV RIPSGQSVVS SSFHSPRVSE EAGDSERLRT ASSALSGAWD 2220
AARDASKAGS ASLHPVFPQK PYHLGDGEGF AVHRKSTLER SGPLSSSPPS QRTAVSPPSR 2280
DKLPSPSAAL SEFVEELRRK RAQRGQGSTL HLGDGPVLPI FQTTRASSLR RGRASSDEGD 2340
LSLKTRVKSP LGAEGIPGAT AGLSRSTSLK CISSEGPEDI TLLPDKQKTR FGSCESLLES 2400
GPCTRRKLSS PTGLLSPTLR PRRPCLESSV DDAISLELGK EPLVFQNRQF SHLMEETLDS 2460
DPFSWKLPSL NYRRQTKVDF DDFLPAIRKS DTPSSGAAKD GKEASKHPGV HFEMGEAADR 2520
SFLSGIKTIL KKSPEVKEDP AHLSDSSSSS SSIVSFKSTG GTGSGPRVPR LQGDGGERMS 2580
PEHRDPGSAR RDDDVESIMR KYLQQ 2605 
Gene Ontology
 GO:0031941; C:filamentous actin; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0016461; C:unconventional myosin complex; IEA:Compara.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0048739; P:cardiac muscle fiber development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0001570; P:vasculogenesis; IMP:MGI. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.