CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006533
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Endoplasmic reticulum transmembrane protein 1 
Protein Synonyms/Alias
  
Gene Name
 YET1 
Gene Synonyms/Alias
 YKL065C; YKL331 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
130SIVKRLVKYQGLINEacetylation[1]
130SIVKRLVKYQGLINEubiquitination[2]
190LEKYFDEKNQPGNVAubiquitination[2, 3, 4, 5]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.
 Hitchcock AL, Auld K, Gygi SP, Silver PA.
 Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12735-40. [PMID: 14557538]
 [4] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [5] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269
Functional Description
 May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. 
Sequence Annotation
 MOTIF 203 206 Di-lysine motif.
 CROSSLNK 190 190 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Isopeptide bond; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 206 AA 
Protein Sequence
MSLYFTTLFL LLTVEMVMLF IFVLPLPFRI RRGIFSTYNQ LTAKQQIKTI IFITGCLVGL 60
LFIDSWKRSQ IRVSLYHNDN SGSIGSSAVT PIQALASRAY NQRNMYISGF ILYFSICIPT 120
VMSIVKRLVK YQGLINEQEK QKLNKPSSNS KKDSNEADST KLQEELRKKQ ISLEGLQKQV 180
KNLEKYFDEK NQPGNVAAAE ASKKGN 206 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 
Interpro
 IPR008417; Bap31. 
Pfam
 PF05529; Bap31 
SMART
  
PROSITE
  
PRINTS