CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022620
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Abhydrolase domain-containing protein 2 
Protein Synonyms/Alias
 Lung alpha/beta hydrolase 2; MmLABH2 
Gene Name
 Abhd2 
Gene Synonyms/Alias
 Labh-2; Labh2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
57GLSRFLLKSCPLLTKubiquitination[1]
265FLMADNMKKIILSHRubiquitination[1]
282LFGDHVKKPQSLEDTubiquitination[1]
310IDDNVMRKFHGYNSLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in smooth muscle cells migration. 
Sequence Annotation
 ACT_SITE 207 207 Charge relay system (By similarity).
 ACT_SITE 345 345 Charge relay system (By similarity).
 ACT_SITE 376 376 Charge relay system (By similarity).  
Keyword
 Complete proteome; Hydrolase; Membrane; Reference proteome; Serine esterase; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 425 AA 
Protein Sequence
MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG LSRFLLKSCP 60
LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF ITMSDGATST FDLFEPLAEH 120
CVGDDITMVI CPGIANHSEK QYIRTFVDYA QKNGYRCAVL NHLGALPNIE LTSPRMFTYG 180
CTWEFGAMVN YIKRTYPQTQ LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL 240
RAQETFMQWD QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL 300
MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE SLLTIPKSLS 360
EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY ANAICQWERN KSQCSDTEQM 420
EAELE 425 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0030336; P:negative regulation of cell migration; IMP:MGI.
 GO:0009611; P:response to wounding; IMP:MGI. 
Interpro
 IPR012020; AB-Hydro_YheT.
 IPR000073; AB_hydrolase_1.
 IPR000952; UPF0017_hydro-like_CS. 
Pfam
 PF00561; Abhydrolase_1 
SMART
  
PROSITE
 PS01133; UPF0017 
PRINTS