CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018798
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Geranylgeranyl transferase type-2 subunit alpha 
Protein Synonyms/Alias
 Geranylgeranyl transferase type II subunit alpha; Rab geranyl-geranyltransferase subunit alpha; Rab GG transferase alpha; Rab GGTase alpha; Rab geranylgeranyltransferase subunit alpha 
Gene Name
 RABGGTA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MHGRLKVKTSEEQAEubiquitination[1]
38ATQAVFQKRQAGELDubiquitination[1, 2, 3, 4]
105SCLRVNPKSYGTWHHubiquitination[1]
329WTAGDVQKECVLLKGubiquitination[1]
335QKECVLLKGRQEGWCubiquitination[1]
402LDPLLYEKETLQYFQubiquitination[1, 3]
412LQYFQTLKAVDPMRAubiquitination[3]
428YLDDLRSKFLLENSVubiquitination[1, 2, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. 
Sequence Annotation
 REPEAT 44 78 PFTA 1.
 REPEAT 88 122 PFTA 2.
 REPEAT 124 158 PFTA 3.
 REPEAT 159 193 PFTA 4.
 REPEAT 207 241 PFTA 5.
 REPEAT 363 397 PFTA 6.
 REPEAT 442 463 LRR 1.
 REPEAT 464 486 LRR 2.
 REPEAT 487 508 LRR 3.
 REPEAT 509 530 LRR 4.
 REPEAT 534 555 LRR 5.
 METAL 2 2 Zinc (By similarity).  
Keyword
 Complete proteome; Leucine-rich repeat; Metal-binding; Polymorphism; Prenyltransferase; Reference proteome; Repeat; Transferase; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 567 AA 
Protein Sequence
MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE LTSQILGANP 60
DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL RVNPKSYGTW HHRCWLLGRL 120
PEPNWTRELE LCARFLEVDE RNFHCWDYRR FVATQAAVPP AEELAFTDSL ITRNFSNYSS 180
WHYRSCLLPQ LHPQPDSGPQ GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD 240
PQDALRCLHV SRDEACLTVS FSRPLLVGSR MEILLLMVDD SPLIVEWRTP DGRNRPSHVW 300
LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ LFRCELSVEK 360
STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY EKETLQYFQT LKAVDPMRAT 420
YLDDLRSKFL LENSVLKMEY AEVRVLHLAH KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP 480
ALAALRCLEV LQASDNAIES LDGVTNLPRL QELLLCNNRL QQPAVLQPLA SCPRLVLLNL 540
QGNPLCQAVG ILEQLAELLP SVSSVLT 567 
Gene Ontology
 GO:0004663; F:Rab geranylgeranyltransferase activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006464; P:cellular protein modification process; TAS:ProtInc.
 GO:0018344; P:protein geranylgeranylation; IEA:Compara.
 GO:0007601; P:visual perception; TAS:ProtInc. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR002088; Prenyl_trans_a.
 IPR009087; RabGGT_asu_insert-domain. 
Pfam
 PF00560; LRR_1
 PF01239; PPTA
 PF07711; RabGGT_insert 
SMART
  
PROSITE
 PS51450; LRR
 PS51147; PFTA 
PRINTS