CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016177
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dipeptidyl peptidase 9 
Protein Synonyms/Alias
 DP9; Dipeptidyl peptidase IV-related protein 2; DPRP-2; Dipeptidyl peptidase IX; DPP IX; Dipeptidyl peptidase-like protein 9; DPLP9 
Gene Name
 DPP9 
Gene Synonyms/Alias
 DPRP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
57AARFQVQKHSWDGLRubiquitination[1]
80YSGLIVNKAPHDFQFubiquitination[1]
90HDFQFVQKTDESGPHubiquitination[1]
123LYSEIPKKVRKEALLubiquitination[1]
126EIPKKVRKEALLLLSubiquitination[1]
196FHCRDGGKNGFMVSPubiquitination[1]
205GFMVSPMKPLEIKTQubiquitination[1]
210PMKPLEIKTQCSGPRubiquitination[1]
347KNPKIALKLAEFQTDubiquitination[1]
358FQTDSQGKIVSTQEKubiquitination[1, 2]
377PFSSLFPKVEYIARAubiquitination[1]
477FLRANECKTGFCHLYubiquitination[1]
616PDDDPLHKQPRFWASubiquitination[1]
723LRFEGALKNQMGQVEubiquitination[1]
857SQLIRAGKPYQLQIYubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. 
Sequence Annotation
 ACT_SITE 730 730 Charge relay system (By similarity).
 ACT_SITE 808 808 Charge relay system (By similarity).
 ACT_SITE 840 840 Charge relay system (By similarity).
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 Acetylation; Alternative splicing; Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 863 AA 
Protein Sequence
MRKVKKLRLD KENTGSWRSF SLNSEGAERM ATTGTPTADR GDAAATDDPA ARFQVQKHSW 60
DGLRSIIHGS RKYSGLIVNK APHDFQFVQK TDESGPHSHR LYYLGMPYGS RENSLLYSEI 120
PKKVRKEALL LLSWKQMLDH FQATPHHGVY SREEELLRER KRLGVFGITS YDFHSESGLF 180
LFQASNSLFH CRDGGKNGFM VSPMKPLEIK TQCSGPRMDP KICPADPAFF SFINNSDLWV 240
ANIETGEERR LTFCHQGLSN VLDDPKSAGV ATFVIQEEFD RFTGYWWCPT ASWEGSEGLK 300
TLRILYEEVD ESEVEVIHVP SPALEERKTD SYRYPRTGSK NPKIALKLAE FQTDSQGKIV 360
STQEKELVQP FSSLFPKVEY IARAGWTRDG KYAWAMFLDR PQQWLQLVLL PPALFIPSTE 420
NEEQRLASAR AVPRNVQPYV VYEEVTNVWI NVHDIFYPFP QSEGEDELCF LRANECKTGF 480
CHLYKVTAVL KSQGYDWSEP FSPGEDEFKC PIKEEIALTS GEWEVLARHG SKIWVNEETK 540
LVYFQGTKDT PLEHHLYVVS YEAAGEIVRL TTPGFSHSCS MSQNFDMFVS HYSSVSTPPC 600
VHVYKLSGPD DDPLHKQPRF WASMMEAASC PPDYVPPEIF HFHTRSDVRL YGMIYKPHAL 660
QPGKKHPTVL FVYGGPQVQL VNNSFKGIKY LRLNTLASLG YAVVVIDGRG SCQRGLRFEG 720
ALKNQMGQVE IEDQVEGLQF VAEKYGFIDL SRVAIHGWSY GGFLSLMGLI HKPQVFKVAI 780
AGAPVTVWMA YDTGYTERYM DVPENNQHGY EAGSVALHVE KLPNEPNRLL ILHGFLDENV 840
HFFHTNFLVS QLIRAGKPYQ LQIYPNERHS IRCPESGEHY EVTLLHFLQE YL 892 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001375; Peptidase_S9.
 IPR002469; Peptidase_S9B. 
Pfam
 PF00930; DPPIV_N
 PF00326; Peptidase_S9 
SMART
  
PROSITE
  
PRINTS