CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010114
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Probable 5-formyltetrahydrofolate cyclo-ligase 
Protein Synonyms/Alias
 5,10-methenyl-tetrahydrofolate synthetase; MTHFS; Methenyl-THF synthetase 
Gene Name
 MPN_348; H91_orf164, MP488 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
120NYRLGFGKGYYDRYLacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819
Functional Description
  
Sequence Annotation
 NP_BIND 3 7 ATP.
 NP_BIND 117 125 ATP.
 REGION 118 122 Substrate binding.
 BINDING 55 55 Substrate.
 BINDING 115 115 Substrate.
 BINDING 154 154 ATP.  
Keyword
 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 164 AA 
Protein Sequence
MDKNALRKQI LQKRMALSTI EKSHLDQKIN QKLVAFLTPK PCIKTIALYE PIKNEVTFVD 60
FFFEFLKINQ IRAVYPKVIS DTEIIFIDQE TNTFEPNQID CFLIPLVGFN KDNYRLGFGK 120
GYYDRYLMQL TRQQPKIGIA YSFQKGDFLA DPWDVQLDLI INDE 164 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030272; F:5-formyltetrahydrofolate cyclo-ligase activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro. 
Interpro
 IPR002698; FTHF_cligase.
 IPR024185; FTHF_cligase-like. 
Pfam
 PF01812; 5-FTHF_cyc-lig 
SMART
  
PROSITE
  
PRINTS