CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020243
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleolar complex protein 4 homolog 
Protein Synonyms/Alias
 NOC4 protein homolog; NOC4-like protein; Nucleolar complex-associated protein 4-like protein 
Gene Name
 NOC4L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89QGATRKYKVWMRHRYubiquitination[1]
115GHPSFQVKELALSALubiquitination[1, 2, 3]
124LALSALLKFVQLEGAubiquitination[1]
136EGAHPLEKSKWEGNYubiquitination[2]
138AHPLEKSKWEGNYLFubiquitination[1, 2, 4, 5, 6]
232TVSSFYVKRAELWDTubiquitination[1, 2]
246TWKVAHLKEHRRVFQubiquitination[2]
342DPSVFHVKYRARFFHubiquitination[1]
485IFERDLKKKGPEPVPubiquitination[1]
486FERDLKKKGPEPVPLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 516 AA 
Protein Sequence
MEREPGAAGV RRALGRRLEA VLASRSEANA VFDILAVLQS EDQEEIQEAV RTCSRLFGAL 60
LERGELFVGQ LPSEEMVMTG SQGATRKYKV WMRHRYHSCC NRLGELLGHP SFQVKELALS 120
ALLKFVQLEG AHPLEKSKWE GNYLFPRELF KLVVGGLLSP EEDQSLLLSQ FREYLDYDDT 180
RYHTMQAAVD AVARVTGQHP EVPPAFWNNA FTLLSAVSLP RREPTVSSFY VKRAELWDTW 240
KVAHLKEHRR VFQAMWLSFL KHKLPLSLYK KVLLIVHDAI LPQLAQPTLM IDFLTRACDL 300
GGALSLLALN GLFILIHKHN LEYPDFYRKL YGLLDPSVFH VKYRARFFHL ADLFLSSSHL 360
PAYLVAAFAK RLARLALTAP PEALLMVLPF ICNLLRRHPA CRVLVHRPHG PELDADPYDP 420
GEEDPAQSRA LESSLWELQA LQRHYHPEVS KAASVINQAL SMPEVSIAPL LELTAYEIFE 480
RDLKKKGPEP VPLEFIPAQG LLGRPGELCA QHFTLS 516 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0006364; P:rRNA processing; ISS:UniProtKB. 
Interpro
 IPR005612; CCAAT-binding_factor.
 IPR027193; Noc4. 
Pfam
 PF03914; CBF 
SMART
  
PROSITE
  
PRINTS