| Tag | Content |
|---|
| CPLM ID | CPLM-014826 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 2',5'-phosphodiesterase 12 |
Protein Synonyms/Alias | 2'-PDE; 2-PDE |
Gene Name | Pde12 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 426 | LNPLAQEKVLQRSSV | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) (By similarity). |
Sequence Annotation | MOD_RES 216 216 Phosphoserine (By similarity). |
Keyword | Complete proteome; Hydrolase; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 608 AA |
Protein Sequence | MWRLPGRAAL RGVRSVVEQR SPAEATTHEA VRAMERAVVR CVPSEPKLSL SFALADGSHK 60
NMQRDQSEPL GRALSRIATN ALKGHAKVAA AKKSRKNRAH SSGGAACAAT GSEPAATCEP 120
VVKLYYREEA VAEDVLNVDA WQDGAVLQIG DVKYKVERNP PAFTELQLPR YIMAGFPVCP 180
KLGLEFGDPA SSVFRWYKEV KPGAAEPGDS GLASSSHSLQ SSAWIETGVD ERVYTPCNAD 240
IGLRLKLHCT PGNGQRFGPS RELESVCPVE AGPGTCTFDH RHLYTKKVTE DSFIRTVSYN 300
ILADTYAQTE FSRTVLYPYC APYALELDYR QNLIQKELTG YNADLICLQE VDRAVFSDSL 360
VPALEAFGLE GVFRIKQHEG LATFYRKSKF RLLSQHDISF QEALKSDPLH KELLEKLALN 420
PLAQEKVLQR SSVLQISVLQ STTDSSKKIC VANTHLYWHP KGGYIRLIQM AAALVHIRHV 480
SCDLYPGIPV IFCGDFNSTP STGMYHFVIN GSVPEDHEDW ASNGEEERCG MSLTHCFKLK 540
SACGEPAYTN YVGGFHGCLD YIFIDLNALE VEQVIPLPSH EEVTTHQALP SVSHPSDHIA 600
LVCDLKWK 608 |
Gene Ontology | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |