UniProt Accession

 JOS2_HUMAN; Q8TAC2; M0QX25 

Genbank Protein ID

 AF247787; AK131052; AC008743; CH471135; BC062416 

Genbank Nucleotide ID

 AAL95692.1; EAW71877.1; AAH62416.1 

Protein Name

 Josephin-2 

Protein Synonyms/Alias

 Josephin domain-containing protein 2 

Gene Name

 JOSD2 

Gene Synonyms/Alias

 SBBI54 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
142	VYYNLDSKLRAPEAL	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme. 

Sequence Annotation

 DOMAIN 11 188 Josephin.
 ACT_SITE 24 24 Nucleophile (By similarity).
 ACT_SITE 125 125 Proton acceptor (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Protease; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 188 AA 

Protein Sequence

Gene Ontology

 GO:0008242; F:omega peptidase activity; IEA:InterPro.
 GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB.
 GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR006155; Josephin. 

Pfam

 PF02099; Josephin 

SMART

  

PROSITE

 PS50957; JOSEPHIN 

PRINTS

 PR01233; JOSEPHIN.