CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022638
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SRC kinase signaling inhibitor 1 
Protein Synonyms/Alias
 SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap 
Gene Name
 Srcin1 
Gene Synonyms/Alias
 P140; Snip 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
268PNTAILIKDEARNVFubiquitination[1]
595FGPPVPAKDTETRERubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. 
Sequence Annotation
 REGION 681 731 Interaction with SNAP25.
 MOD_RES 79 79 Phosphoserine (By similarity).
 MOD_RES 98 98 Phosphoserine (By similarity).
 MOD_RES 175 175 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphoserine (By similarity).
 MOD_RES 260 260 Phosphoserine (By similarity).
 MOD_RES 276 276 Phosphotyrosine (By similarity).
 MOD_RES 342 342 Phosphoserine (By similarity).
 MOD_RES 378 378 Phosphoserine (By similarity).
 MOD_RES 397 397 Phosphoserine (By similarity).
 MOD_RES 431 431 Phosphotyrosine (By similarity).
 MOD_RES 547 547 Phosphoserine (By similarity).
 MOD_RES 556 556 Phosphoserine (By similarity).
 MOD_RES 637 637 Phosphoserine (By similarity).
 MOD_RES 671 671 Phosphothreonine (By similarity).
 MOD_RES 900 900 Phosphoserine (By similarity).
 MOD_RES 941 941 Phosphoserine (By similarity).
 MOD_RES 1021 1021 Phosphoserine (By similarity).
 MOD_RES 1077 1077 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Exocytosis; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1197 AA 
Protein Sequence
MQPWQCLRRF ALAWWERTAE GRARSPREEV GPRDPGGRGE PDPERSSPPM LSADDAEYPR 60
EYRTLGGGGS GGSGGRRFSN VGLVHTSERR HTVIAAQSLE ALSGLQKADA DRKRDAFMDH 120
LKSKYPQHAL ALRGQQDRMR EQQPNYWSFK TRSSRHTQGA QPGLADQAAK LSYASAESLE 180
TMSEAELPLG FSRMNRFRQS LPLSRSASQT KLRSPGVLFL QFGEETRRVH ITHEVSSLDT 240
LHALIAHMFP QKLTMGMLKS PNTAILIKDE ARNVFYELED VRDIQDRSII KIYRKEPLYA 300
AFPGSHLTNG DLRREMVYAS RESSPTRRLN NLSPASHLAS SSPPPGLPSG LPSGLPSGSP 360
SRSRLSYAGG RPPSYAGSPV HHAAERLGGA PTSQGVSPSP SAILERRDVK PDEDLAGKAG 420
GMVLVKGEGL YADPYGLLHE GRLSLAAAAG DPFAYPGAGG LYKRGSVRSL STYSAAALQS 480
DLEDSLYKAG AGGPLYGDGY GFRLPPSSPQ KLADVSAPSG GPPPPHSPYS GPPSRGSPVR 540
QSFRKDSGSS SVFAESPGGK ARSTGASTAG APPSELFPGP GERSLVGFGP PVPAKDTETR 600
ERMEAMEKQI ASLTGLVQSA LLRGSEPETP SEKIEGSNGA ATPSAPVCGS GSRSSGATPV 660
SGPPPPAVSS TPAGQPTAVS RLQMQMHLRG LQNSASDLRG QLQQLRKLQL QNQESVRALL 720
KRTEAELSMR VSEAARRQED PLQRQRTLVE EERLRYLNDE ELITQQLNDL EKSVEKIQRD 780
VAHNHRLVPG PELEEKALVL KQLGETLTEL KAHFPGLQSK MRVVLRVEVE AVKFLKEEPQ 840
RLDGLLKRCR VVTDTLAQIR RQVDEGVWPP PNNLLNQSPK KVAAETDFSK GLDFEIPPPS 900
PPLNLHELSG PAEGTPLTPK SGNPTKGLDA PSKRNMDKAV SVEAAERDWE EKRAALTQYS 960
AKDINRLLEE TQAELLKAIP DLDCASKTHP GPTPTPDHKP PKAPHGQKAA PRTEPSGRRG 1020
SDELTVPRYR TEKPSKSPPP PPPRRSFPSS HGLTTTRTGE VVVTSKKDSV FIKKAESEEL 1080
EIQKPQVKLR RAVSEVVRPA STPPIMASAI KDEDDEERII AELESGGGSV PPMKVVTPGA 1140
SRLKAAQGPA GSPDKGKHGK QRTEYMRIQA QQQVRVGYQA PRPLEGCTPR LCYMPLS 1197 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:RGD.
 GO:0030424; C:axon; IDA:UniProtKB.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0030175; C:filopodium; IDA:RGD.
 GO:0030027; C:lamellipodium; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IDA:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0019904; F:protein domain specific binding; IDA:RGD.
 GO:0019901; F:protein kinase binding; ISS:UniProtKB.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0007162; P:negative regulation of cell adhesion; IEA:Compara.
 GO:0050709; P:negative regulation of protein secretion; IMP:RGD.
 GO:0061099; P:negative regulation of protein tyrosine kinase activity; ISS:UniProtKB.
 GO:0061098; P:positive regulation of protein tyrosine kinase activity; ISS:UniProtKB.
 GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
 GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
 GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB. 
Interpro
 IPR026727; Srcin1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS