UniProt Accession

 RS2_YEAST; P25443; D6VU25 

Genbank Protein ID

 M59375; X94106; Z72645; AY557815; BK006941 

Genbank Nucleotide ID

 AAA63576.1; CAA63835.1; CAA96831.1; AAS56141.1; DAA07986.1 

Protein Name

 40S ribosomal protein S2 

Protein Synonyms/Alias

 Omnipotent suppressor protein SUP44; RP12; S4; YS5 

Gene Name

 RPS2 

Gene Synonyms/Alias

 RPS4; SUP38; SUP44; YGL123W; G2893 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
10	APEAQQQKRGGFGGR	acetylation	[1]
33	GPRNTEEKGWVPVTK	acetylation	[1]
33	GPRNTEEKGWVPVTK	ubiquitination	[2, 3, 4]
119	GLGIKTAKEVAGAIR	acetylation	[1]
119	GLGIKTAKEVAGAIR	ubiquitination	[4]
157	QPHSLATKTTGKCGS	acetylation	[1]
161	LATKTTGKCGSVTVR	ubiquitination	[4]
185	IVASPAVKKLLQLAG	ubiquitination	[4]
186	VASPAVKKLLQLAGV	ubiquitination	[4]
251	SDEASAQKKRF****	ubiquitination	[3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis.
 Ziv I, Matiuhin Y, Kirkpatrick DS, Erpapazoglou Z, Leon S, Pantazopoulou M, Kim W, Gygi SP, Haguenauer-Tsapis R, Reis N, Glickman MH, Kleifeld O.
 Mol Cell Proteomics. 2011 May;10(5):M111.009753. [PMID: 21427232]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [4] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Important in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. 

Sequence Annotation

 DOMAIN 76 139 S5 DRBM.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Reference proteome; Ribonucleoprotein; Ribosomal protein; Ribosome biogenesis; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 254 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IDA:SGD.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0070181; F:SSU rRNA binding; IDA:SGD.
 GO:0003735; F:structural constituent of ribosome; IDA:SGD.
 GO:0045903; P:positive regulation of translational fidelity; IMP:SGD.
 GO:0006407; P:rRNA export from nucleus; IMP:SGD.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR014720; dsRNA-bd-like_dom.
 IPR000851; Ribosomal_S5.
 IPR005324; Ribosomal_S5_C.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
 IPR005711; Ribosomal_S5_euk/arc.
 IPR013810; Ribosomal_S5_N.
 IPR018192; Ribosomal_S5_N_CS. 

Pfam

 PF00333; Ribosomal_S5
 PF03719; Ribosomal_S5_C 

SMART

  

PROSITE

 PS00585; RIBOSOMAL_S5
 PS50881; S5_DSRBD 

PRINTS