| Tag | Content |
|---|
| CPLM ID | CPLM-007246 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PHO85 cyclin-6 |
Protein Synonyms/Alias | |
Gene Name | PCL6 |
Gene Synonyms/Alias | YER059W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 28 | YSIQSDDKANLGSGN | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL7, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. The PCL6-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase. PCL6-PHO85 also phosphorylates YJL084C. |
Sequence Annotation | MOD_RES 61 61 Phosphoserine.
MOD_RES 281 281 Phosphoserine.
MOD_RES 312 312 Phosphoserine.
MOD_RES 317 317 Phosphothreonine. |
Keyword | Carbohydrate metabolism; Complete proteome; Cyclin; Cytoplasm; Glycogen metabolism; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 420 AA |
Protein Sequence | MSIKGDSPSS TNASSSPKST YSIQSDDKAN LGSGNVDIRT DNSQQDSNNR RDIVVVTRVA 60
SEETLESQSS TSSMGIRPES SFNYEDASNQ ARVEMNNRVH GSNMNTINKY YPVRFPKNNE 120
RQLSDTNNLN EKVQGTHTVQ SSTQEDKILD GDTSNSQVTP SLNIAEFPTD KLLKMLTALL 180
TKIIKSNDRT AATNPSLTQE IENGRCLALS DNEKKYLSPV LGFRGKHVPQ IGLDQYFQRI 240
QKYCPTTNDV FLSLLVYFDR ISKRCNSVTT TPKTNTAKHE SPSNESSLDK ANRGADKMSA 300
CNSNENNEND DSDDENTGVQ RDSRAHPQMF VMDSHNIHRL IIAGITVSTK FLSDFFYSNS 360
RYSRVGGISL QELNHLELQF LVLCDFELLI SVNELQRYAD LLYRFWNNAK AQSQALVTGM 420 |
Gene Ontology | GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; TAS:SGD. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; TAS:SGD. GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW. GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro. GO:0005979; P:regulation of glycogen biosynthetic process; IGI:SGD. GO:0005981; P:regulation of glycogen catabolic process; IGI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |