CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039023
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase 
Protein Synonyms/Alias
  
Gene Name
 Nedd4l 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
503FPVHMRSKASLNPNDubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 939 AA 
Protein Sequence
FPCSDPYVKL SLYVADENRE LALVQTKTIK KTLNPKWNEE FYFRVNPSNH RLLFEVFDEN 60
RLTRDDFLGQ VDVPLSHLPT EDPTMERPYT FKDFLLRPRS HKSRVKGFLR LKMAYMPKNG 120
GQDEENSEQR DDMEHGWEVV DSNDSASQHQ EELPPPPLPP GWEEKVDNLG RTYYVNHNNR 180
STQWHRPSLM DVSSESDNNI RQINQEAAHR RFRSRRHISE DLEPEASEGG GEGPEPWETI 240
SEEVNMAGDS LSLALPPPPA SPVSRTSPQE LSEELSRRLQ ITPDSNGEQF SALIQREPSS 300
RLRSCSVTDA VAEQAHLPPP STPTRRARSS TVTGGEESTP SVAYVHTTPG LPSGWEERKD 360
AKGRTYYVNH NNRTTTWTRP IMQLAEDGAS GSATNSNNHL VEPQIRRPRS LSSPTVTLSA 420
PLEGAKDSPI RRAVKDTLSN PQSPQPSPYN SPKPQHKVTQ SFLPPGWEMR IAPNGRPFFI 480
DHNTKTTTWE DPRLKFPVHM RSKASLNPND LGPLPPGWEE RIHLDGRTFY IDHNSKITQW 540
EDPRLQNPAI TGPAVPYSRE FKQKYDYFRK KLKKPADIPN RFEMKLHRNN IFEESYRRIM 600
SVKRPDVLKA RLWIEFESEK GLDYGGVARE WFFLLSKEMF NPYYGLFEYS ATDNYTLQIN 660
PNSGLCNEDH LSYFTFIGRV AGLAVFHGKL LDGFFIRPFY KMMLGKQITL NDMESVDSEY 720
YNSLKWILEN DPTELDLMFC IDEENFGQTY QVDLKPNGSE IMVTNENKRE YIDLVIQWRF 780
VNRVQKQMNA FLEGFTELLP IDLIKIFDEN ELELLMCGLG DVDVNDWRQH SIYKNGYCPN 840
HPVIQWFWKA VLLMDAEKRI RLLQFVTGTS RVPMNGFAEL YGSNGPQLFT IEQWGSPEKL 900
PRAHTCFNRL DLPPYETFED LREKLLMAVE NAQGFEGVD 939 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:RGD.
 GO:0045732; P:positive regulation of protein catabolic process; IMP:RGD.
 GO:0006513; P:protein monoubiquitination; IMP:RGD.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR024928; E3_ub_ligase_SMURF1.
 IPR000569; HECT.
 IPR001202; WW_dom. 
Pfam
 PF00168; C2
 PF00632; HECT
 PF00397; WW 
SMART
 SM00239; C2
 SM00119; HECTc
 SM00456; WW 
PROSITE
 PS50004; C2
 PS50237; HECT
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS