CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014216
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anoctamin-1 
Protein Synonyms/Alias
 Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2 
Gene Name
 ANO1 
Gene Synonyms/Alias
 DOG1; ORAOV2; TAOS2; TMEM16A 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84KINSVLQKITDPIQPubiquitination[1]
183NVEFNDRKLLYEEWAubiquitination[1]
197ARYGVFYKYQPIDLVubiquitination[1]
446CIARWLTKIEVPKTEubiquitination[1]
635RPVAVRAKDIGIWYNubiquitination[1]
795FMREEQDKQQLLETWubiquitination[1]
805LLETWMEKERQKDEPubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. 
Sequence Annotation
 CARBOHYD 832 832 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Calcium; Cell membrane; Chloride; Chloride channel; Complete proteome; Cytoplasm; Developmental protein; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 986 AA 
Protein Sequence
MDYHEDDKRF RREEYEGNLL EAGLELERDE DTKIHGVGFV KIHAPWNVLC REAEFLKLKM 60
PTKKMYHINE TRGLLKKINS VLQKITDPIQ PKVAEHRPQT MKRLSYPFSR EKQHLFDLSD 120
KDSFFDSKTR STIVYEILKR TTCTKAKYSM GITSLLANGV YAAAYPLHDG DYNGENVEFN 180
DRKLLYEEWA RYGVFYKYQP IDLVRKYFGE KIGLYFAWLG VYTQMLIPAS IVGIIVFLYG 240
CATMDENIPS MEMCDQRHNI TMCPLCDKTC SYWKMSSACA TARASHLFDN PATVFFSVFM 300
ALWAATFMEH WKRKQMRLNY RWDLTGFEEE EDHPRAEYEA RVLEKSLKKE SRNKETDKVK 360
LTWRDRFPAY LTNLVSIIFM IAVTFAIVLG VIIYRISMAA ALAMNSSPSV RSNIRVTVTA 420
TAVIINLVVI ILLDEVYGCI ARWLTKIEVP KTEKSFEERL IFKAFLLKFV NSYTPIFYVA 480
FFKGRFVGRP GDYVYIFRSF RMEECAPGGC LMELCIQLSI IMLGKQLIQN NLFEIGIPKM 540
KKLIRYLKLK QQSPPDHEEC VKRKQRYEVD YNLEPFAGLT PEYMEMIIQF GFVTLFVASF 600
PLAPLFALLN NIIEIRLDAK KFVTELRRPV AVRAKDIGIW YNILRGIGKL AVIINAFVIS 660
FTSDFIPRLV YLYMYSKNGT MHGFVNHTLS SFNVSDFQNG TAPNDPLDLG YEVQICRYKD 720
YREPPWSENK YDISKDFWAV LAARLAFVIV FQNLVMFMSD FVDWVIPDIP KDISQQIHKE 780
KVLMVELFMR EEQDKQQLLE TWMEKERQKD EPPCNHHNTK ACPDSLGSPA PSHAYHGGVL 840 
Gene Ontology
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005229; F:intracellular calcium activated chloride channel activity; IDA:UniProtKB.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 
Interpro
 IPR007632; Anoctamin. 
Pfam
 PF04547; Anoctamin 
SMART
  
PROSITE
  
PRINTS