CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013284
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 La-related protein 7 
Protein Synonyms/Alias
 La ribonucleoprotein domain family member 7; P-TEFb-interaction protein for 7SK stability; PIP7S 
Gene Name
 LARP7 
Gene Synonyms/Alias
 HDCMA18P 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
318KVKKIIQKDIIKEASacetylation[1]
574AKTQQASKHIRFSEYacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. 
Sequence Annotation
 DOMAIN 28 122 HTH La-type RNA-binding.
 DOMAIN 125 203 RRM.
 MOD_RES 257 257 Phosphothreonine.
 MOD_RES 258 258 Phosphoserine.
 MOD_RES 261 261 Phosphoserine.
 MOD_RES 273 273 Phosphoserine.
 MOD_RES 337 337 Phosphoserine.
 MOD_RES 338 338 Phosphothreonine.
 MOD_RES 440 440 Phosphothreonine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Dwarfism; Mental retardation; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 582 AA 
Protein Sequence
METESGNQEK VMEEESTEKK KEVEKKKRSR VKQVLADIAK QVDFWFGDAN LHKDRFLREQ 60
IEKSRDGYVD ISLLVSFNKM KKLTTDGKLI ARALRSSAVV ELDLEGTRIR RKKPLGERPK 120
DEDERTVYVE LLPKNVNHSW IERVFGKCGN VVYISIPHYK STGDPKGFAF VEFETKEQAA 180
KAIEFLNNPP EEAPRKPGIF PKTVKNKPIP ALRVVEEKKK KKKKKGRMKK EDNIQAKEEN 240
MDTSNTSISK MKRSRPTSEG SDIESTEPQK QCSKKKKKRD RVEASSLPEV RTGKRKRSSS 300
EDAESLAPRS KVKKIIQKDI IKEASEASKE NRDIEISTEE EKDTGDLKDS SLLKTKRKHK 360
KKHKERHKMG EEVIPLRVLS KSEWMDLKKE YLALQKASMA SLKKTISQIK SESEMETDSG 420
VPQNTGMKNE KTANREECRT QEKVNATGPQ FVSGVIVKII STEPLPGRKQ VRDTLAAISE 480
VLYVDLLEGD TECHARFKTP EDAQAVINAY TEINKKHCWK LEILSGDHEQ RYWQKILVDR 540
QAKLNQPREK KRGTEKLITK AEKIRLAKTQ QASKHIRFSE YD 582 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0030529; C:ribonucleoprotein complex; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006396; P:RNA processing; IEA:InterPro. 
Interpro
 IPR002344; Lupus_La.
 IPR006630; Lupus_La_RNA-bd.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR014886; RRM_3.
 IPR000504; RRM_dom.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF05383; La
 PF00076; RRM_1
 PF08777; RRM_3 
SMART
 SM00715; LA
 SM00360; RRM 
PROSITE
 PS50961; HTH_LA
 PS50102; RRM 
PRINTS
 PR00302; LUPUSLA.