| Tag | Content |
|---|
| CPLM ID | CPLM-007323 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phospholipid:diacylglycerol acyltransferase |
Protein Synonyms/Alias | PDAT |
Gene Name | LRO1 |
Gene Synonyms/Alias | YNR008W; N2042 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 278 | VIGYEPNKMTSAAYD | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid. |
Sequence Annotation | ACT_SITE 324 324 Acyl-ester intermediate (Potential).
ACT_SITE 567 567 Charge relay system (By similarity).
ACT_SITE 618 618 Charge relay system (By similarity). |
Keyword | Acyltransferase; Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 661 AA |
Protein Sequence | MGTLFRRNVQ NQKSDSDENN KGGSVHNKRE SRNHIHHQQG LGHKRRRGIS GSAKRNERGK 60
DFDRKRDGNG RKRWRDSRRL IFILGAFLGV LLPFSFGAYH VHNSDSDLFD NFVNFDSLKV 120
YLDDWKDVLP QGISSFIDDI QAGNYSTSSL DDLSENFAVG KQLLRDYNIE AKHPVVMVPG 180
VISTGIESWG VIGDDECDSS AHFRKRLWGS FYMLRTMVMD KVCWLKHVML DPETGLDPPN 240
FTLRAAQGFE STDYFIAGYW IWNKVFQNLG VIGYEPNKMT SAAYDWRLAY LDLERRDRYF 300
TKLKEQIELF HQLSGEKVCL IGHSMGSQII FYFMKWVEAE GPLYGNGGRG WVNEHIDSFI 360
NAAGTLLGAP KAVPALISGE MKDTIQLNTL AMYGLEKFFS RIERVKMLQT WGGIPSMLPK 420
GEEVIWGDMK SSSEDALNNN TDTYGNFIRF ERNTSDAFNK NLTMKDAINM TLSISPEWLQ 480
RRVHEQYSFG YSKNEEELRK NELHHKHWSN PMEVPLPEAP HMKIYCIYGV NNPTERAYVY 540
KEEDDSSALN LTIDYESKQP VFLTEGDGTV PLVAHSMCHK WAQGASPYNP AGINVTIVEM 600
KHQPDRFDIR GGAKSAEHVD ILGSAELNDY ILKIASGNGD LVEPRQLSNL SQWVSQMPFP 660
M 661 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005811; C:lipid particle; IDA:SGD. GO:0097038; C:perinuclear endoplasmic reticulum; IDA:SGD. GO:0008374; F:O-acyltransferase activity; IEA:InterPro. GO:0046027; F:phospholipid:diacylglycerol acyltransferase activity; IDA:SGD. GO:0006672; P:ceramide metabolic process; IDA:SGD. GO:0019915; P:lipid storage; IMP:SGD. GO:0019432; P:triglyceride biosynthetic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |