CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein mago nashi homolog 2 
Protein Synonyms/Alias
  
Gene Name
 MAGOHB 
Gene Synonyms/Alias
 MAGOH2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18YYVGHKGKFGHEFLEubiquitination[1, 2, 3, 4, 5]
33FEFRPDGKLRYANNSubiquitination[2, 4]
43YANNSNYKNDVMIRKubiquitination[1, 2, 3, 4, 5, 6, 7]
56RKEAYVHKSVMEELKubiquitination[4]
63KSVMEELKRIIDDSEubiquitination[4]
73IDDSEITKEDDALWPubiquitination[2, 4]
116LIDVNQSKDPEGLRVubiquitination[2, 3, 4, 6]
132YYLVQDLKCLVFSLIubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
 Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; mRNA transport; Nucleus; Polymorphism; Reference proteome; RNA-binding; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 148 AA 
Protein Sequence
MAVASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK EAYVHKSVME 60
ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS FTTSKIGSLI DVNQSKDPEG 120
LRVFYYLVQD LKCLVFSLIG LHFKIKPI 148 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR004023; Mago_nashi. 
Pfam
 PF02792; Mago_nashi 
SMART
  
PROSITE
  
PRINTS