UniProt Accession

 COMD6_HUMAN; Q7Z4G1; A6NF28; B7ZLN0; Q5TBK4 

Genbank Protein ID

 AY542161; AF169971; AL137244; AL137244; BC117391; BC143912; BC171758 

Genbank Nucleotide ID

 AAS22243.1; AAQ13599.1; CAI12417.1; CAQ09795.1; AAI17392.1; AAI43913.1; AAI71758.1 

Protein Name

 COMM domain-containing protein 6 

Protein Synonyms/Alias

  

Gene Name

 COMMD6 

Gene Synonyms/Alias

 MSTP076 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
39	SDTCRSLKYPYVAVM	acetylation	[1]
39	SDTCRSLKYPYVAVM	ubiquitination	[2, 3, 4]
48	PYVAVMLKVADHSGQ	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation. 

Sequence Annotation

 DOMAIN 18 85 COMM.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 85 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:MGI. 

Interpro

 IPR017920; COMM.
 IPR009886; HCaRG. 

Pfam

 PF07258; HCaRG 

SMART

  

PROSITE

 PS51269; COMM 

PRINTS