UniProt Accession

 DPOD4_HUMAN; Q9HCU8; F5H506 

Genbank Protein ID

 AF179890; AY928482; AP003419; BG403692 

Genbank Nucleotide ID

 AAG08966.1; AAX09676.1 

Protein Name

 DNA polymerase delta subunit 4 

Protein Synonyms/Alias

 DNA polymerase delta subunit p12 

Gene Name

 POLD4 

Gene Synonyms/Alias

 POLDS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	TDSYPVVKRREGPAG	ubiquitination	[1]
25	EGPAGHSKGELAPEL	ubiquitination	[2, 3, 4]
74	LQRWCRAKQMGLEPP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Nucleus; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 107 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003887; F:DNA-directed DNA polymerase activity; TAS:ProtInc.
 GO:0006284; P:base-excision repair; TAS:Reactome.
 GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0006297; P:nucleotide-excision repair, DNA gap filling; TAS:Reactome.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:0000722; P:telomere maintenance via recombination; TAS:Reactome.
 GO:0032201; P:telomere maintenance via semi-conservative replication; TAS:Reactome.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome. 

Interpro

 IPR007218; DNA_pol_delta_4. 

Pfam

 PF04081; DNA_pol_delta_4 

SMART

  

PROSITE

  

PRINTS