UniProt Accession

 SNX3_YEAST; Q08826; D6W352 

Genbank Protein ID

 AF016101; Z75265; BK006948 

Genbank Nucleotide ID

 AAC15913.1; CAA99686.1; DAA11118.1 

Protein Name

 Sorting nexin-3 

Protein Synonyms/Alias

 Golgi retention deficient protein 19 

Gene Name

 SNX3 

Gene Synonyms/Alias

 GRD19; YOR357C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
13	KSFGSTEKSLLSKGH	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)). 

Sequence Annotation

 DOMAIN 38 161 PX.
 BINDING 81 81 Phosphatidylinositol 3-phosphate.
 BINDING 83 83 Phosphatidylinositol 3-phosphate; via
 BINDING 112 112 Phosphatidylinositol 3-phosphate.
 BINDING 127 127 Phosphatidylinositol 3-phosphate.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Golgi apparatus; Lipid-binding; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 162 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005768; C:endosome; IDA:SGD.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0034499; P:late endosome to Golgi transport; IMP:SGD.
 GO:0008104; P:protein localization; IMP:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR001683; Phox. 

Pfam

 PF00787; PX 

SMART

 SM00312; PX 

PROSITE

 PS50195; PX 

PRINTS