| Tag | Content |
|---|
| CPLM ID | CPLM-000541 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Klotho |
Protein Synonyms/Alias | Klotho peptide |
Gene Name | Kl |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 856 | VVPWGLRKVLNWLRF | ubiquitination | [1] | | 894 | SLRIYYIKNYVNEAL | ubiquitination | [1] | | 948 | PSMKHYRKIIDSNGF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. |
Sequence Annotation | REGION 59 508 Glycosyl hydrolase-1 1.
REGION 517 955 Glycosyl hydrolase-1 2.
MOD_RES 499 499 Phosphotyrosine.
CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).
CARBOHYD 285 285 N-linked (GlcNAc...) (Potential).
CARBOHYD 346 346 N-linked (GlcNAc...) (Potential).
CARBOHYD 609 609 N-linked (GlcNAc...) (Potential).
CARBOHYD 614 614 N-linked (GlcNAc...) (Potential).
CARBOHYD 696 696 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Glycosidase; Hydrolase; Membrane; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1014 AA |
Protein Sequence | MLARAPPRRP PRLVLLRLLL LHLLLLALRA RCLSAEPGQG AQTWARFARA PAPEAAGLLH 60
DTFPDGFLWA VGSAAYQTEG GWRQHGKGAS IWDTFTHHSG AAPSDSPIVV APSGAPSPPL 120
SSTGDVASDS YNNVYRDTEG LRELGVTHYR FSISWARVLP NGTAGTPNRE GLRYYRRLLE 180
RLRELGVQPV VTLYHWDLPQ RLQDTYGGWA NRALADHFRD YAELCFRHFG GQVKYWITID 240
NPYVVAWHGY ATGRLAPGVR GSSRLGYLVA HNLLLAHAKV WHLYNTSFRP TQGGRVSIAL 300
SSHWINPRRM TDYNIRECQK SLDFVLGWFA KPIFIDGDYP ESMKNNLSSL LPDFTESEKR 360
LIRGTADFFA LSFGPTLSFQ LLDPNMKFRQ LESPNLRQLL SWIDLEYNHP PIFIVENGWF 420
VSGTTKRDDA KYMYYLKKFI METLKAIRLD GVDVIGYTAW SLMDGFEWHR GYSIRRGLFY 480
VDFLSQDKEL LPKSSALFYQ KLIEDNGFPP LPENQPLEGT FPCDFAWGVV DNYVQVDTTL 540
SQFTDPNVYL WDVHHSKRLI KVDGVVAKKR KPYCVDFSAI RPQITLLREM RVTHFRFSLD 600
WALILPLGNQ TQVNHTVLHF YRCMISELVH ANITPVVALW QPAAPHQGLP HALAKHGAWE 660
NPHTALAFAD YANLCFKELG HWVNLWITMN EPNTRNMTYR AGHHLLRAHA LAWHLYDDKF 720
RAAQKGKISI ALQADWIEPA CPFSQNDKEV AERVLEFDIG WLAEPIFGSG DYPRVMRDWL 780
NQKNNFLLPY FTEDEKKLVR GSFDFLAVSH YTTILVDWEK EDPMKYNDYL EVQEMTDITW 840
LNSPSQVAVV PWGLRKVLNW LRFKYGDLPM YVTANGIDDD PHAEQDSLRI YYIKNYVNEA 900
LKAYVLDDIN LCGYFAYSLS DRSAPKSGFY RYAANQFEPK PSMKHYRKII DSNGFLGSGT 960
LGRFCPEEYT VCTECGFFQT RKSLLVFISF LVFTFIISLA LIFHYSKKGQ RSYK 1014 |
Gene Ontology | GO:0005576; C:extracellular region; ISS:MGI. GO:0016021; C:integral to membrane; ISS:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004566; F:beta-glucuronidase activity; IEA:EC. GO:0002526; P:acute inflammatory response; IEA:Compara. GO:0007568; P:aging; IMP:MGI. GO:0055074; P:calcium ion homeostasis; IGI:MGI. GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. GO:0006112; P:energy reserve metabolic process; IMP:MGI. GO:0030501; P:positive regulation of bone mineralization; IEA:Compara. GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |