UniProt Accession

 QCR6_HUMAN; P07919; B2R4V9; D3DQ18; Q5TDF6; Q6LDB8; Q9BQ91 

Genbank Protein ID

 M36647; Y00764; BT007070; AK311967; AL122001; CH471059; CH471059; BC001426; BC001934; BC015177; BC107703; S61826 

Genbank Nucleotide ID

 AAA36317.1; CAA68733.1; AAP35733.1; BAG34906.1; CAI21963.1; EAX06922.1; EAX06924.1; AAH01426.1; AAH01934.1; AAH15177.1; AAI07704.1; AAD13930.1 

Protein Name

 Cytochrome b-c1 complex subunit 6, mitochondrial 

Protein Synonyms/Alias

 Complex III subunit 6; Complex III subunit VIII; Cytochrome c1 non-heme 11 kDa protein; Mitochondrial hinge protein; Ubiquinol-cytochrome c reductase complex 11 kDa protein 

Gene Name

 UQCRH 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
42	EQCEQLEKCVKARER	acetylation	[1]
42	EQCEQLEKCVKARER	ubiquitination	[2]
85	RDHCVAHKLFNNLK*	acetylation	[1, 3, 4]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. 

Sequence Annotation

 MOD_RES 42 42 N6-acetyllysine (By similarity).
 MOD_RES 63 63 Phosphothreonine (By similarity).
 MOD_RES 85 85 N6-acetyllysine.
 DISULFID 37 81 By similarity.
 DISULFID 53 67 By similarity.  

Keyword

 Acetylation; Complete proteome; Disulfide bond; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Polymorphism; Reference proteome; Respiratory chain; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 91 AA 

Protein Sequence

Gene Ontology

 GO:0005746; C:mitochondrial respiratory chain; TAS:ProtInc.
 GO:0005750; C:mitochondrial respiratory chain complex III; IEA:Compara.
 GO:0008121; F:ubiquinol-cytochrome-c reductase activity; TAS:ProtInc.
 GO:0009060; P:aerobic respiration; TAS:ProtInc.
 GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IEA:InterPro.
 GO:0006119; P:oxidative phosphorylation; TAS:ProtInc.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR003422; Cyt_b-c1_6.
 IPR023184; Ubol_cytC_Rdtase_hinge_dom. 

Pfam

 PF02320; UCR_hinge 

SMART

  

PROSITE

  

PRINTS