| Tag | Content |
|---|
| CPLM ID | CPLM-015577 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PH domain leucine-rich repeat-containing protein phosphatase 2 |
Protein Synonyms/Alias | PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like |
Gene Name | PHLPP2 |
Gene Synonyms/Alias | KIAA0931; PHLPPL |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 141 | MIRFYGEKPCHMDRL | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. |
Sequence Annotation | DOMAIN 150 248 PH.
REPEAT 250 271 LRR 1.
REPEAT 273 296 LRR 2.
REPEAT 300 321 LRR 3.
REPEAT 323 344 LRR 4.
REPEAT 346 368 LRR 5.
REPEAT 369 390 LRR 6.
REPEAT 392 412 LRR 7.
REPEAT 416 439 LRR 8.
REPEAT 440 460 LRR 9.
REPEAT 461 480 LRR 10.
REPEAT 481 502 LRR 11.
REPEAT 503 524 LRR 12.
REPEAT 526 547 LRR 13.
REPEAT 549 570 LRR 14.
REPEAT 571 592 LRR 15.
REPEAT 595 616 LRR 16.
REPEAT 621 644 LRR 17.
REPEAT 645 666 LRR 18.
REPEAT 669 690 LRR 19.
REPEAT 692 713 LRR 20.
REPEAT 714 735 LRR 21.
REPEAT 737 758 LRR 22.
DOMAIN 775 1031 PP2C-like.
METAL 820 820 Manganese 1 (By similarity).
METAL 820 820 Manganese 2 (By similarity).
METAL 821 821 Manganese 1; via carbonyl oxygen (By
METAL 985 985 Manganese 2 (By similarity).
METAL 1024 1024 Manganese 2 (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Leucine-rich repeat; Manganese; Membrane; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Repeat; Tumor suppressor. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1323 AA |
Protein Sequence | MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTTS SSSSSSSSSS 60
DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT ERPLQIVYDY LSRLGFDDPV 120
RIQEEATNPD LGCMIRFYGE KPCHMDRLDR ILLSGIYNVR KGKTQLHKWA ERLVVLCGTC 180
LIVSSVKDCQ TGKMHILPLV GGKIEEVKRR QYSLAFSSAG AQAQTYHVSF ETLAEYQRWQ 240
RQASKVVSQR ISTVDLSCYS LEEVPEHLFY SQDITYLNLR HNFMQLERPG GLDTLYKFSQ 300
LKGLNLSHNK LGLFPILLCE ISTLTELNLS CNGFHDLPSQ IGNLLNLQTL CLDGNFLTTL 360
PEELGNLQQL SSLGISFNNF SQIPEVYEKL TMLDRVVMAG NCLEVLNLGV LNRMNHIKHV 420
DLRMNHLKTM VIENLEGNKH ITHVDLRDNR LTDLDLSSLC SLEQLHCGRN QLRELTLSGF 480
SLRTLYASSN RLTAVNVYPV PSLLTFLDLS RNLLECVPDW ACEAKKIEVL DVSYNLLTEV 540
PVRILSSLSL RKLMLGHNHV QNLPTLVEHI PLEVLDLQHN ALTRLPDTLF SKALNLRYLN 600
ASANSLESLP SACTGEESLS MLQLLYLTNN LLTDQCIPVL VGHLHLRILH LANNQLQTFP 660
ASKLNKLEQL EELNLSGNKL KTIPTTIANC KRLHTLVAHS NNISIFPEIL QLPQIQFVDL 720
SCNDLTEILI PEALPATLQD LDLTGNTNLV LEHKTLDIFS HITTLKIDQK PLPTTDSTVT 780
STFWSHGLAE MAGQRNKLCV SALAMDSFAE GVGAVYGMFD GDRNEELPRL LQCTMADVLL 840
EEVQQSTNDT VFMANTFLVS HRKLGMAGQK LGSSALLCYI RPDTADPASS FSLTVANVGT 900
CQAVLCRGGK PVPLSKVFSL EQDPEEAQRV KDQKAIITED NKVNGVTCCT RMLGCTYLYP 960
WILPKPHISS TPLTIQDELL ILGNKALWEH LSYTEAVNAV RHVQDPLAAA KKLCTLAQSY 1020
GCQDNVGAMV VYLNIGEEGC TCEMNGLTLP GPVGFASTTT IKDAPKPATP SSSSGIASEF 1080
SSEMSTSEVS SEVGSTASDE HNAGGLDTAL LPRPERRCSL HPTPTSGLFQ RQPSSATFSS 1140
NQSDNGLDSD DDQPVEGVIT NGSKVEVEVD IHCCRGRDLE NSPPLIESSP TLCSEEHARG 1200
SCFGIRRQNS VNSGMLLPMS KDRMELQKSP STSCLYGKKL SNGSIVPLED SLNLIEVATE 1260
VPKRKTGYFA APTQMEPEDQ FVVPHDLEEE VKEQMKQHQD SRLEPEPHEE DRTEPPEEFD 1320
TAL 1323 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0001917; C:photoreceptor inner segment; IEA:Compara. GO:0042622; C:photoreceptor outer segment membrane; IEA:Compara. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara. GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome. GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome. GO:0045087; P:innate immune response; TAS:Reactome. GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome. GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome. GO:0006470; P:protein dephosphorylation; IEA:Compara. |
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