UniProt Accession

 ADR1_HUMAN; Q96A54; B3KMB0; Q53HS7; Q53YY6; Q9Y360 

Genbank Protein ID

 AY424279; AF125179; AF151803; AK001484; AK222503; CH471067; BC001594; BC010743 

Genbank Nucleotide ID

 AAR08367.1; AAQ13552.1; AAD34040.1; BAG50922.1; BAD96223.1; EAW91450.1; AAH01594.1; AAH10743.1 

Protein Name

 Adiponectin receptor protein 1 

Protein Synonyms/Alias

 Progestin and adipoQ receptor family member I 

Gene Name

 ADIPOR1 

Gene Synonyms/Alias

 PAQR1; TESBP1A; CGI-45 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
79	QAHHAMEKMEEFVYK	ubiquitination	[1]
86	KMEEFVYKVWEGRWR	ubiquitination	[2, 3]
126	PSFRACFKSIFRIHT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. 

Sequence Annotation

  

Keyword

 Complete proteome; Fatty acid metabolism; Lipid metabolism; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0042562; F:hormone binding; IDA:UniProtKB.
 GO:0004872; F:receptor activity; IEA:Compara.
 GO:0019395; P:fatty acid oxidation; IDA:UniProtKB.
 GO:0009755; P:hormone-mediated signaling pathway; IDA:UniProtKB. 

Interpro

 IPR004254; HlyIII-related. 

Pfam

 PF03006; HlyIII 

SMART

  

PROSITE

  

PRINTS