CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020142
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol polyphosphate 5-phosphatase K 
Protein Synonyms/Alias
 Skeletal muscle and kidney-enriched inositol phosphatase 
Gene Name
 INPP5K 
Gene Synonyms/Alias
 PPS; SKIP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
220CYGGLWEKDQLSIAKubiquitination[1]
228DQLSIAKKHDPLLREubiquitination[1]
248LLFPPTYKFDRNSNDubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton. 
Sequence Annotation
 REGION 16 318 Catalytic (Potential).
 REGION 321 448 Required for ruffle localization.  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Hydrolase; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 448 AA 
Protein Sequence
MSSRKLSGPK GRRLSIHVVT WNVASAAPPL DLSDLLQLNN RNLNLDIYVI GLQELNSGII 60
SLLSDAAFND SWSSFLMDVL SPLSFIKVSH VRMQGILLLV FAKYQHLPYI QILSTKSTPT 120
GLFGYWGNKG GVNICLKLYG YYVSIINCHL PPHISNNYQR LEHFDRILEM QNCEGRDIPN 180
ILDHDLIIWF GDMNFRIEDF GLHFVRESIK NRCYGGLWEK DQLSIAKKHD PLLREFQEGR 240
LLFPPTYKFD RNSNDYDTSE KKRKPAWTDR ILWRLKRQPC AGPDTPIPPA SHFSLSLRGY 300
SSHMTYGISD HKPVSGTFDL ELKPLVSAPL IVLMPEDLWT VENDMMVSYS STSDFPSSPW 360
DWIGLYKVGL RDVNDYVSYA WVGDSKVSCS DNLNQVYIDI SNIPTTEDEF LLCYYSNSLR 420
SVVGISRPFQ IPPGSLREDP LGEAQPQI 448 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0043005; C:neuron projection; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0032587; C:ruffle membrane; IDA:UniProtKB.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0016312; F:inositol bisphosphate phosphatase activity; IDA:MGI.
 GO:0046030; F:inositol trisphosphate phosphatase activity; IDA:MGI.
 GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.
 GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.
 GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.
 GO:0042577; F:lipid phosphatase activity; NAS:UniProtKB.
 GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.
 GO:0005000; F:vasopressin receptor activity; ISS:UniProtKB.
 GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.
 GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.
 GO:0032869; P:cellular response to insulin stimulus; IDA:UniProtKB.
 GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.
 GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.
 GO:0043922; P:negative regulation by host of viral transcription; IDA:UniProtKB.
 GO:0051926; P:negative regulation of calcium ion transport; IDA:UniProtKB.
 GO:0035305; P:negative regulation of dephosphorylation; ISS:UniProtKB.
 GO:0010829; P:negative regulation of glucose transport; IDA:UniProtKB.
 GO:2000466; P:negative regulation of glycogen (starch) synthase activity; ISS:UniProtKB.
 GO:0045719; P:negative regulation of glycogen biosynthetic process; IDA:UniProtKB.
 GO:0046627; P:negative regulation of insulin receptor signaling pathway; IDA:UniProtKB.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.
 GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IDA:UniProtKB.
 GO:0051898; P:negative regulation of protein kinase B signaling cascade; IDA:UniProtKB.
 GO:0090315; P:negative regulation of protein targeting to membrane; IDA:UniProtKB.
 GO:0045869; P:negative regulation of retroviral genome replication; IDA:UniProtKB.
 GO:0051497; P:negative regulation of stress fiber assembly; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.
 GO:2001153; P:positive regulation of renal water transport; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.
 GO:0072661; P:protein targeting to plasma membrane; ISS:UniProtKB.
 GO:0097178; P:ruffle assembly; IDA:UniProtKB. 
Interpro
 IPR005135; Endo/exonuclease/phosphatase.
 IPR000300; IPPc. 
Pfam
 PF03372; Exo_endo_phos 
SMART
 SM00128; IPPc 
PROSITE
  
PRINTS