CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038627
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myosin-binding protein C, cardiac-type 
Protein Synonyms/Alias
  
Gene Name
 Mybpc3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
14LKMPEPGKKPVSAFNubiquitination[1]
95AVIAGSSKVKFDLKVubiquitination[1]
110TEPAPPEKAESEVAPubiquitination[1]
191VAGASLLKPPVVKWFubiquitination[1]
306LDFSSLLKKRDFRRDubiquitination[1]
315RDFRRDSKLEAPAEEubiquitination[1]
383YQVNKGHKIRLTVELubiquitination[1]
398ADPDAEVKWLKNGQEubiquitination[1]
401DAEVKWLKNGQEIQMubiquitination[1]
421IFESVGAKRTLTISQubiquitination[1]
453CSTELFVKEPPVLITubiquitination[1]
491GAQVKWLKDGVELTRubiquitination[1]
546AELIVQEKKLEVYQSubiquitination[1]
547ELIVQEKKLEVYQSIubiquitination[1]
568AKDQAVFKCEVSDENubiquitination[1]
695KTVTQGKKASTGPHPubiquitination[1]
718DEEWVFDKKLLCETEubiquitination[1]
719EEWVFDKKLLCETEGubiquitination[1]
935ERTSMLVKDLPTGARubiquitination[1]
962PGGPIVTKEPVTVQEubiquitination[1]
1003LLIPFQGKPRPQVTWubiquitination[1]
1153NMVGSSDKAAATKEPubiquitination[1]
1158SDKAAATKEPVFIPRubiquitination[1]
1174GITYEPPKYKALDFSubiquitination[1]
1176TYEPPKYKALDFSEAubiquitination[1]
1219KPKISWFKNGLDLGEubiquitination[1]
1235ARFRMFCKQGVLTLEubiquitination[1]
1245VLTLEIRKPCPYDGGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1277 AA 
Protein Sequence
MPGVTVLKMP EPGKKPVSAF NKKPRSAEVT AGSAAVFEAE TERSGVKVRW QRDGSDITAN 60
DKYGLAAEGK RHTLTVRDAS PDDQGSYAVI AGSSKVKFDL KVTEPAPPEK AESEVAPGAP 120
KEVPAPATEL EESVSSPEGS VSVTQDGSAA EHQGAPDDPI GLFLMRPQDG EVTVGGSIVF 180
SARVAGASLL KPPVVKWFKG KWVDLSSKVG QHLQLHDSYD RASKVYLFEL HITDAQTTSA 240
GGYRCEVSTK DKFDSCNFNL TVHEAIGSGD LDLRSAFRRT SLAGAGRRTS DSHEDAGTLD 300
FSSLLKKRDF RRDSKLEAPA EEDVWEILRQ APPSEYERIA FQHGVTDLRG MLKRLKGMKQ 360
DEKKSTAFQK KLEPAYQVNK GHKIRLTVEL ADPDAEVKWL KNGQEIQMSG SKYIFESVGA 420
KRTLTISQCS LADDAAYQCV VGGEKCSTEL FVKEPPVLIT RSLEDQLVMV GQRVEFECEV 480
SEEGAQVKWL KDGVELTREE TFKYRFKKDG RKHHLIINEA TLEDAGHYAV RTSGGQSLAE 540
LIVQEKKLEV YQSIADLAVG AKDQAVFKCE VSDENVRGVW LKNGKELVPD NRIKVSHIGR 600
VHKLTIDDVT PADEADYSFV PEGFACNLSA KLHFMEVKID FVPRQEPPKI HLDCPGSTPD 660
TIVVVAGNKL RLDVPISGDP APTVVWQKTV TQGKKASTGP HPDAPEDAGA DEEWVFDKKL 720
LCETEGRVRV ETTKDRSVFT VEGAEKEDEG VYTVTVKNPV GEDQVNLTVK VIDVPDAPAA 780
PKISNVGEDS CTVQWEPPAY DGGQPVLGYI LERKKKKSYR WMRLNFDLLR ELSHEARRMI 840
EGVAYEMRVY AVNAVGMSRP SPASQPFMPI GPPGEPTHLA VEDVSDTTVS LKWRPPERVG 900
AGGLDGYSVE YCQEGCSEWT PALQGLTERT SMLVKDLPTG ARLLFRVRAH NVAGPGGPIV 960
TKEPVTVQEI LQRPRLQLPR HLRQTIQKKV GEPVNLLIPF QGKPRPQVTW TKEGQPLAGE 1020
EVSIRNSPTD TILFIRAARR THSGTYQVTV RIENMEDKAT LILQIVDKPS PPQDIRIVET 1080
WGFNVALEWK PPQDDGNTEI WGYTVQKADK KTMEWFTVLE HYRRTHCVVS ELIIGNGYYF 1140
RVFSHNMVGS SDKAAATKEP VFIPRPGITY EPPKYKALDF SEAPSFTQPL ANRSIIAGYN 1200
AILCCAVRGS PKPKISWFKN GLDLGEDARF RMFCKQGVLT LEIRKPCPYD GGVYVCRATN 1260
LQGEAQCECR LEVRVPQ 1277 
Gene Ontology
 GO:0031672; C:A band; IDA:MGI.
 GO:0005856; C:cytoskeleton; TAS:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0060048; P:cardiac muscle contraction; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IMP:MGI.
 GO:0031034; P:myosin filament assembly; IMP:MGI.
 GO:0002027; P:regulation of heart rate; IMP:MGI.
 GO:0045214; P:sarcomere organization; IMP:MGI. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS