CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022218
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein asunder homolog 
Protein Synonyms/Alias
 Cell cycle regulator Mat89Bb homolog; Germ cell tumor 1; Sarcoma antigen NY-SAR-95 
Gene Name
 ASUN 
Gene Synonyms/Alias
 C12orf11; GCT1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
35VEFDMLVKNRTQGIIubiquitination[1]
73MYDIFPFKKLVNFIVubiquitination[1, 2, 3]
74YDIFPFKKLVNFIVSubiquitination[1]
135AAVETLCKITEYQHEubiquitination[1]
167IICITNAKSDSHVRMubiquitination[1]
188ETIHEHNKLAANSDHubiquitination[1]
223SLVSDRSKKELSPVLubiquitination[1]
224LVSDRSKKELSPVLTubiquitination[1]
295DAHVDFLKSGDSHLGubiquitination[1]
436PFLDPRYKIDGSLEVubiquitination[1]
496EDVLNCQKTIYNLVDubiquitination[1]
507NLVDMERKNDPLPISubiquitination[1]
595VKDYEQEKSWQDSERubiquitination[1]
648TPQVEKSKGPVSLLSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. 
Sequence Annotation
 MOD_RES 626 626 Phosphoserine.  
Keyword
 Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Mitosis; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MKIFSESHKT VFVVDHCPYM AESCRQHVEF DMLVKNRTQG IIPLAPISKS LWTCSVESSM 60
EYCRIMYDIF PFKKLVNFIV SDSGAHVLNS WTQEDQNLQE LMAALAAVGP PNPRADPECC 120
SILHGLVAAV ETLCKITEYQ HEARTLLMEN AERVGNRGRI ICITNAKSDS HVRMLEDCVQ 180
ETIHEHNKLA ANSDHLMQIQ KCELVLIHTY PVGEDSLVSD RSKKELSPVL TSEVHSVRAG 240
RHLATKLNIL VQQHFDLAST TITNIPMKEE QHANTSANYD VELLHHKDAH VDFLKSGDSH 300
LGGGSREGSF KETITLKWCT PRTNNIELHY CTGAYRISPV DVNSRPSSCL TNFLLNGRSV 360
LLEQPRKSGS KVISHMLSSH GGEIFLHVLS SSRSILEDPP SISEGCGGRV TDYRITDFGE 420
FMRENRLTPF LDPRYKIDGS LEVPLERAKD QLEKHTRYWP MIISQTTIFN MQAVVPLASV 480
IVKESLTEED VLNCQKTIYN LVDMERKNDP LPISTVGTRG KGPKRDEQYR IMWNELETLV 540
RAHINNSEKH QRVLECLMAC RSKPPEEEER KKRGRKREDK EDKSEKAVKD YEQEKSWQDS 600
ERLKGILERG KEELAEAEII KDSPDSPEPP NKKPLVEMDE TPQVEKSKGP VSLLSLWSNR 660
INTANSRKHQ EFAGRLNSVN NRAELYQHLK EENGMETTEN GKASRQ 706 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
 GO:0007346; P:regulation of mitotic cell cycle; IMP:UniProtKB.
 GO:0030317; P:sperm motility; ISS:UniProtKB. 
Interpro
 IPR019355; Cell_cycle_regulator_Mat89Bb. 
Pfam
 PF10221; DUF2151 
SMART
  
PROSITE
  
PRINTS