UniProt Accession

 Q91XH5_MOUSE; Q91XH5 

Genbank Protein ID

 AC153373; BC010400; BC054423; CH466523 

Genbank Nucleotide ID

 AAH10400.1; AAH54423.1; EDK99121.1 

Protein Name

 Sepiapterin reductase 

Protein Synonyms/Alias

 Sepiapterin reductase, isoform CRA_b 

Gene Name

 Spr 

Gene Synonyms/Alias

 mCG_128676 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
52	ESMLRQLKEELGAQQ	acetylation	[1]
52	ESMLRQLKEELGAQQ	ubiquitination	[2]
175	WGLYCAGKAARDMLY	ubiquitination	[2]
227	RSKLQKLKSDGALVD	ubiquitination	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 262 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004757; F:sepiapterin reductase activity; IEA:InterPro.
 GO:0048667; P:cell morphogenesis involved in neuron differentiation; IMP:MGI.
 GO:0016265; P:death; IMP:MGI.
 GO:0042417; P:dopamine metabolic process; IMP:MGI.
 GO:0006558; P:L-phenylalanine metabolic process; IMP:MGI.
 GO:0042415; P:norepinephrine metabolic process; IMP:MGI.
 GO:0019889; P:pteridine metabolic process; IMP:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
 GO:0042428; P:serotonin metabolic process; IMP:MGI.
 GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
 GO:0046146; P:tetrahydrobiopterin metabolic process; IMP:MGI.
 GO:0050882; P:voluntary musculoskeletal movement; IMP:MGI. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR006393; Sepiapterin_red. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

  

PRINTS

 PR00081; GDHRDH.