CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012339
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol 1,4,5-trisphosphate receptor type 3 
Protein Synonyms/Alias
 IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor 
Gene Name
 ITPR3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92ADVVLLQKLQHAAQMubiquitination[1, 2]
236DHLEEVLKGGDVVRLubiquitination[1, 3]
324AEENPSYKGDASDPKubiquitination[1]
376LDPTTLQKTDSFVPRubiquitination[4]
545LEELSDQKNAPYQHMubiquitination[1, 2]
706KNNEHHEKSVRQLAQubiquitination[1]
813IPTAITIKDYDSNLNubiquitination[1, 2]
932STMVLSRKQSVFSAPubiquitination[1, 2, 3]
1111VENYKVIKSELDRLRubiquitination[1]
1123RLRTMVEKSELWVDKubiquitination[2]
1130KSELWVDKKGSGKGEubiquitination[2]
1164FLHPPGEKSSENYQIubiquitination[2]
1216LLQIPYDKGDAKMMEubiquitination[1]
1589TANQWDYKNIIEKLQubiquitination[5, 6]
1652SKLIQHTKDLMESEEubiquitination[1]
1827EPVDPTTKGRVASFSubiquitination[1, 2]
1998QLKDNASKLLLALMEubiquitination[1, 2]
2030QELVDVIKKAYLQEEubiquitination[1, 2]
2031ELVDVIKKAYLQEEEubiquitination[1]
2094SMLSLNNKQLSQMLKubiquitination[1, 2]
2101KQLSQMLKSSAPAQEubiquitination[1, 2]
2167EQDEQGSKVSDFFDQubiquitination[1, 2]
2360ETLFNVIKSVTRNGRubiquitination[1]
2597VAQMIKNKNLDWFPRubiquitination[1, 2]
2628EIRILQDKLNSTMKLubiquitination[1]
2634DKLNSTMKLVSHLTAubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. 
Sequence Annotation
 DOMAIN 113 173 MIR 1.
 DOMAIN 174 224 MIR 2.
 DOMAIN 232 288 MIR 3.
 DOMAIN 295 372 MIR 4.
 DOMAIN 378 434 MIR 5.
 REGION 266 270 Inositol 1,4,5-trisphosphate binding (By
 REGION 507 510 Inositol 1,4,5-trisphosphate binding (By
 REGION 567 569 Inositol 1,4,5-trisphosphate binding (By
 MOD_RES 916 916 Phosphoserine.
 MOD_RES 934 934 Phosphoserine.
 MOD_RES 1813 1813 Phosphoserine.
 MOD_RES 1832 1832 Phosphoserine.
 MOD_RES 2583 2583 Phosphotyrosine (Potential).
 MOD_RES 2670 2670 Phosphoserine.  
Keyword
 Calcium; Calcium channel; Calcium transport; Complete proteome; Endoplasmic reticulum; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2671 AA 
Protein Sequence
MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC 60
PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS 120
VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG 180
DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV 240
VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 300
NGLYRFKHLA TGNYLAAEEN PSYKGDASDP KAAGMGAQGR TGRRNAGEKI KYCLVAVPHG 360
NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDIEEE RPIRLMLGTC 420
PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV 480
FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQVFG ILKAPFREKG GEGPLVRLEE 540
LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 600
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE LICKCVLDPK 660
NSDILIRTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDKN NEHHEKSVRQ LAQEARAGNA 720
HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISQQLGVDLI FLCMADEMLP FDLRASFCHL 780
MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ANTMEFVEDY 840
LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA 900
MLQAYEDPGG KNVRRSIQGV GHMMSTMVLS RKQSVFSAPS LSAGASAAEP LDRSKFEENE 960
DIVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSTT 1020
ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLI HLTMHDYAPL VSGALQLLFK 1080
HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSGKGEEVE 1140
AGAAKDKKER PTDEEGFLHP PGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM 1200
DAHKVMLDLL QIPYDKGDAK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL HLFLTPGLLE 1260
AETMQHIFLN NYQLCSEISE PVLQHFVHLL ATHGRHVQYL DFLHTVIKAE GKYVKKCQDM 1320
IMTELTNAGD DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN 1380
VYTEIKCTSL LPLEDVVSVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL 1440
FENFTLDMAR VCSKREKRVA DPTLEKYVLS VVLDTINAFF SSPFSENSTS LQTHQTIVVQ 1500
LLQSTTRLLE CPWLQQQHKG SVEACIRTLA MVAKGRAILL PMDLDAHISS MLSSGASCAA 1560
AAQRNASSYK ATTRAFPRVT PTANQWDYKN IIEKLQDIIT ALEERLKPLV QAELSVLVDV 1620
LHWPELLFLE GSEAYQRCES GGFLSKLIQH TKDLMESEEK LCIKVLRTLQ QMLLKKTKYG 1680
DRGNQLRKML LQNYLQNRKS TSRGDLPDPI GTGLDPDWSA IAATQCRLDK EGATKLVCDL 1740
ITSTKNEKIF QESIGLAIHL LDGGNTEIQK SFHNLMMSDK KSERFFKVLH DRMKRAQQET 1800
KSTVAVNMND LGSQPHEDRE PVDPTTKGRV ASFSIPGSSS RYSLGPSLRR GHEVSERVQS 1860
SEMGTSVLIM QPILRFLQLL CENHNRDLQN FLRCQNNKTN YNLVCETLQF LDIMCGSTTG 1920
GLGLLGLYIN EDNVGLVIQT LETLTEYCQG PCHENQTCIV THESNGIDII TALILNDISP 1980
LCKYRMDLVL QLKDNASKLL LALMESRHDS ENAERILISL RPQELVDVIK KAYLQEEERE 2040
NSEVSPREVG HNIYILALQL SRHNKQLQHL LKPVKRIQEE EAEGISSMLS LNNKQLSQML 2100
KSSAPAQEEE EDPLAYYENH TSQIEIVRQD RSMEQIVFPV PGICQFLTEE TKHRLFTTTE 2160
QDEQGSKVSD FFDQSSFLHN EMEWQRKLRS MPLIYWFSRR MTLWGSISFN LAVFINIIIA 2220
FFYPYMEGAS TGVLDSPLIS LLFWILICFS IAALFTKRYS IRPLIVALIL RSIYYLGIGP 2280
TLNILGALNL TNKIVFVVSF VGNRGTFIRG YKAMVMDMEF LYHVGYILTS VLGLFAHELF 2340
YSILLFDLIY REETLFNVIK SVTRNGRSIL LTALLALILV YLFSIVGFLF LKDDFILEVD 2400
RLPNNHSTAS PLGMPHGAAA FVDTCSGDKM DCVSGLSVPE VLEEDRELDS TERACDTLLM 2460
CIVTVMNHGL RNGGGVGDIL RKPSKDESLF PARVVYDLLF FFIVIIIVLN LIFGVIIDTF 2520
ADLRSEKQKK EEILKTTCFI CGLERDKFDN KTVSFEEHIK LEHNMWNYLY FIVLVRVKNK 2580
TDYTGPESYV AQMIKNKNLD WFPRMRAMSL VSNEGEGEQN EIRILQDKLN STMKLVSHLT 2640
AQLNELKEQM TEQRKRRQRL GFVDVQNCIS R 2671 
Gene Ontology
 GO:0045177; C:apical part of cell; ISS:BHF-UCL.
 GO:0005903; C:brush border; ISS:BHF-UCL.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:BHF-UCL.
 GO:0043209; C:myelin sheath; ISS:BHF-UCL.
 GO:0043025; C:neuronal cell body; ISS:BHF-UCL.
 GO:0005640; C:nuclear outer membrane; ISS:BHF-UCL.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:Compara.
 GO:0031095; C:platelet dense tubular network membrane; TAS:Reactome.
 GO:0043533; F:inositol 1,3,4,5 tetrakisphosphate binding; ISS:BHF-UCL.
 GO:0070679; F:inositol 1,4,5 trisphosphate binding; IDA:BHF-UCL.
 GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; ISS:UniProtKB.
 GO:0000822; F:inositol hexakisphosphate binding; ISS:BHF-UCL.
 GO:0005218; F:intracellular ligand-gated calcium channel activity; ISS:UniProtKB.
 GO:0035091; F:phosphatidylinositol binding; IEA:Compara.
 GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.
 GO:0060402; P:calcium ion transport into cytosol; ISS:UniProtKB.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:BHF-UCL.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0051291; P:protein heterooligomerization; ISS:BHF-UCL.
 GO:0051260; P:protein homooligomerization; ISS:BHF-UCL.
 GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
 GO:0051592; P:response to calcium ion; IDA:BHF-UCL.
 GO:0050913; P:sensory perception of bitter taste; IEA:Compara.
 GO:0050916; P:sensory perception of sweet taste; IEA:Compara.
 GO:0050917; P:sensory perception of umami taste; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR000699; Ca-rel_channel.
 IPR014821; Ins145_P3_rcpt.
 IPR000493; InsP3_rcpt-bd.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR015925; Ryanodine_recept-rel. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF01365; RYDR_ITPR 
SMART
 SM00472; MIR 
PROSITE
 PS50919; MIR 
PRINTS
 PR00779; INSP3RECEPTR.