UniProt Accession

 FKB1A_RAT; Q62658; A0JN04; P97533 

Genbank Protein ID

 U09386; U69485; D86641; BC070519; BC126071 

Genbank Nucleotide ID

 AAA19163.1; AAB48933.1; BAA13153.1; AAH70519.3; AAI26072.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase FKBP1A 

Protein Synonyms/Alias

 PPIase FKBP1A; 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase 

Gene Name

 Fkbp1a 

Gene Synonyms/Alias

 Fkbp1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
48	RDRNKPFKFTLGKQE	acetylation	[1]
53	PFKFTLGKQEVIRGW	acetylation	[1]
53	PFKFTLGKQEVIRGW	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). 

Sequence Annotation

 DOMAIN 20 108 PPIase FKBP-type.
 MOD_RES 2 2 N-acetylglycine (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Isomerase; Phosphoprotein; Reference proteome; Rotamase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 108 AA 

Protein Sequence

Gene Ontology

 GO:0043679; C:axon terminus; IDA:RGD.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0033017; C:sarcoplasmic reticulum membrane; IBA:RefGenome.
 GO:0005528; F:FK506 binding; IDA:RGD.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0034713; F:type I transforming growth factor beta receptor binding; IDA:BHF-UCL.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0060347; P:heart trabecula formation; IEA:Compara.
 GO:0006936; P:muscle contraction; IEA:Compara.
 GO:0032513; P:negative regulation of protein phosphatase type 2B activity; IBA:RefGenome.
 GO:0001933; P:negative regulation of protein phosphorylation; IEA:Compara.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IBA:RefGenome.
 GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0031000; P:response to caffeine; IEA:Compara.
 GO:0010039; P:response to iron ion; IEP:RGD.
 GO:0042098; P:T cell proliferation; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 

Interpro

 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 

Pfam

 PF00254; FKBP_C 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE 

PRINTS