UniProt Accession

 CCD14_HUMAN; Q49A88; B7Z2T2; B8ZZ41; B8ZZ58; D3DN98; Q7Z3N3; Q86T30; Q8IWF8; Q8WUJ8; Q96K47; Q9H9A3; Q9UFH0 

Genbank Protein ID

 BX537652; AL122079; AL833312; AK022954; AK027607; AK295091; AC117381; CH471052; CH471052; BC020246; BC040285; BC042613 

Genbank Nucleotide ID

 CAD97804.1; CAB59254.1; CAD91162.1; BAB14329.1; BAB55229.1; BAH11968.1; EAW79430.1; EAW79434.1; AAH20246.1; AAH40285.1; AAH42613.1 

Protein Name

 Coiled-coil domain-containing protein 14 

Protein Synonyms/Alias

  

Gene Name

 CCDC14 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
163	TIPLVVQKETSSSDN	ubiquitination	[1]
171	ETSSSDNKKQIPNEA	ubiquitination	[1]
172	TSSSDNKKQIPNEAS	ubiquitination	[1]
291	SQFASQGKTVSATCT	ubiquitination	[1]
317	GVPCSLPKTDISAIP	ubiquitination	[1]
343	LPQQGIHKETDLLKC	ubiquitination	[1, 2]
349	HKETDLLKCIQTYLS	ubiquitination	[1]
389	FLATNEEKCAREQIR	ubiquitination	[1, 2, 3, 4]
403	REATSERKDLNIHVR	ubiquitination	[1]
435	AEKVRIIKYLLGELK	ubiquitination	[1]
442	KYLLGELKALVAEQE	ubiquitination	[2]
510	QQLREQQKTQKPSGA	ubiquitination	[2]
551	SQELLQSKNEELLKV	ubiquitination	[1]
574	KKFSSIFKDKDQTIL	ubiquitination	[1, 2]
576	FSSIFKDKDQTILEN	ubiquitination	[1, 2]
584	DQTILENKQQYDIEI	ubiquitination	[1]
606	EEALVNVKSSQFKLE	ubiquitination	[1, 2]
617	FKLETAEKENQILGI	ubiquitination	[1]
649	TLQTSMAKLLSDLSV	ubiquitination	[1, 3, 5]
662	SVDSARCKPGNNLTK	ubiquitination	[1]
669	KPGNNLTKSLLNIHD	ubiquitination	[1]
677	SLLNIHDKQLQHDPA	ubiquitination	[1]
722	EETIEPDKTYENVLS	ubiquitination	[1, 2]
821	SGLAVSGKENKLCTP	ubiquitination	[1, 2]
824	AVSGKENKLCTPVIC	ubiquitination	[1]
836	VICSSSTKEAEDAPE	ubiquitination	[1]
844	EAEDAPEKLSRASDM	ubiquitination	[1, 2]
852	LSRASDMKDTQLLKK	ubiquitination	[1, 2]
859	KDTQLLKKIKEAIGK	ubiquitination	[1]
872	GKIPAATKEPEEQTA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

  

Sequence Annotation

  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 953 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS