CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020162
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 THUMP domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 THUMPD2 
Gene Synonyms/Alias
 C2orf8 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
439HTDEPGIKKCLNPEEubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 DOMAIN 161 266 THUMP.  
Keyword
 Alternative splicing; Complete proteome; Methyltransferase; Reference proteome; RNA-binding; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 503 AA 
Protein Sequence
MSEARGEPGS GPEAGARFFC TAGRGLEPFV MREVRARLAA TQVEYISGKV FFTTCSDLNM 60
LKKLKSAERL FLLIKKQFPL IISSVSKGKI FNEMQRLINE DPGSWLNAIS IWKNLLELDA 120
KKEKLSQRDD NQLKRKVGEN EIIAKKLKIE QMQKIEENRD CQLEKQIKEE TLEQRDFTTK 180
SEKFQEEEFQ NDIEKAIDTH NQNDLTFRVS CRCSGTIGKA FTAQEVGKVI GIAIMKHFGW 240
KADLRNPQLE IFIHLNDIYS VVGIPVFRVS LASRAYIKTA GLRSTIAWAM ASLADIKAGA 300
FVLDPMCGLG TILLEAAKEW PDVYYVGADV SDSQLLGTWD NLKAAGLEDK IELLKISVIE 360
LPLPSESVDI IISDIPFGKK FKLGKDIKSI LQEMERVLHV GGTIVLLLSE DHHRRLTDCK 420
ESNIPFNSKD SHTDEPGIKK CLNPEEKTGA FKTASTSFEA SNHKFLDRMS PFGSLVPVEC 480
YKVSLGKTDA FICKYKKSHS SGL 503 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR000241; RNA_methylase_dom.
 IPR004114; THUMP. 
Pfam
 PF02926; THUMP
 PF01170; UPF0020 
SMART
 SM00981; THUMP 
PROSITE
 PS51165; THUMP 
PRINTS