CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015007
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family F member 1 
Protein Synonyms/Alias
 ATP-binding cassette 50 
Gene Name
 Abcf1 
Gene Synonyms/Alias
 Abc50 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
341KGKTTLLKHIANRALacetylation[1]
445MQNRPTQKFSGGWRMubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity). 
Sequence Annotation
 DOMAIN 298 542 ABC transporter 1.
 DOMAIN 619 834 ABC transporter 2.
 NP_BIND 330 337 ATP 1 (By similarity).
 NP_BIND 652 659 ATP 2 (By similarity).
 MOD_RES 22 22 Phosphoserine (By similarity).
 MOD_RES 105 105 Phosphoserine (By similarity).
 MOD_RES 109 109 Phosphoserine; by CK2 (By similarity).
 MOD_RES 140 140 Phosphoserine; by CK2 (By similarity).
 MOD_RES 197 197 Phosphoserine (By similarity).
 MOD_RES 589 589 Phosphoserine (By similarity).
 CROSSLNK 567 567 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 576 576 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Activator; ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 839 AA 
Protein Sequence
MPKGPKQQPP EPEWIGDGEG TSPADKVVKK GKKDKKTKKT FFEELAVEDK QAGEEEKLQK 60
EKEQQQQQQQ QKKKRDTRKG RRKKDVDDDD DGDERVLMER LKQLSVPASD EEDEVPVPVP 120
RGRKKAKGGN VFEALIQDES EEEKEEEEEK PVLKPAKPEK NRINKAVAEE PPGLRNKKGK 180
EEKSKGKAKN KPSATDSEGE DDEDMTKEKE PPRPGKDKDK KGAEQGSEEE KEEKEGEVKA 240
NDPYAHLSKK EKKKLKKQMD YERQVESLKA ANAAENDFSV SQAEVSSRQA MLENASDIKL 300
EKFSISAHGK ELFVNADLYI VAGRRYGLVG PNGKGKTTLL KHIANRALSI PPNIDVLLCE 360
QEVVADETPA VQAVLRADTK RLRLLEEEKR LQGQLEQGDD TAAEKLEKVY EELRATGAAA 420
AEAKARRILA GLGFDPEMQN RPTQKFSGGW RMRVSLARAL FMEPTLLMLD EPTNHLDLNA 480
VIWLNNYLQG WRKTLLIVSH DQGFLDDVCT DIIHLDTQRL HYYRGNYMTF KKMYQQKQKE 540
LLKQYEKQEK KLKELKAGGK STKQAEKQTK EVLTRKQQKC RRKNQDEESQ DPPELLKRPR 600
EYTVRFTFPD PPPLSPPVLG LHGVTFGYEG QKPLFKNLDF GIDMDSRICI VGPNGVGKST 660
LLLLLTGKLT PTNGEMRKNH RLKIGFFNQQ YAEQLHMEET PTEYLQRGFN LPYQDARKCL 720
GRFGLESHAH TIQICKLSGG QKARVVFAEL ACREPDVLIL DEPTNNLDIE SIDALGEAIN 780
EYKGAVIVVS HDARLITETN CQLWVVEEQS VSQIDGDFDD YKREVLEALG EVMVNRPRD 839 
Gene Ontology
 GO:0005635; C:nuclear envelope; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; ISS:UniProtKB.
 GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0043022; F:ribosome binding; ISS:UniProtKB.
 GO:0008494; F:translation activator activity; ISS:UniProtKB.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006413; P:translational initiation; ISS:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS