UniProt Accession

 CUE1_YEAST; P38428; D6W090; Q03507 

Genbank Protein ID

 Z49260; AY557973; M88172; BK006946 

Genbank Nucleotide ID

 CAA89247.1; AAS56299.1; AAA35221.1; DAA10164.1 

Protein Name

 Coupling of ubiquitin conjugation to ER degradation protein 1 

Protein Synonyms/Alias

 Kinetochore-defect suppressor 4 

Gene Name

 CUE1 

Gene Synonyms/Alias

 KIS4; YMR264W; YM8156.06 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
196	ETKLQSDKDLQSLLT	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER- membrane proteins with misfolded transmembrane domains (ERAD-M). Has also a role in cold adaptation, perhaps through effects on sterol biosynthesis. 

Sequence Annotation

 DOMAIN 65 107 CUE.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 203 AA 

Protein Sequence

Gene Ontology

 GO:0000837; C:Doa10p ubiquitin ligase complex; IDA:SGD.
 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0097027; F:ubiquitin-protein ligase activator activity; IDA:SGD.
 GO:0030433; P:ER-associated protein catabolic process; IMP:SGD.
 GO:0097051; P:establishment of protein localization to endoplasmic reticulum membrane; IMP:SGD. 

Interpro

 IPR003892; CUE. 

Pfam

 PF02845; CUE 

SMART

 SM00546; CUE 

PROSITE

 PS51140; CUE 

PRINTS