CPLM-021383

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-021383

UniProt Accession

OSBL3_HUMAN; Q9H4L5; A4D167; A4D168; A4D169; A4D170; A4D171; A4D172; B8ZZ79; B8ZZP0; O14591; O43357; O43358; Q8N702; Q8N703; Q8N704; Q8NFH0; Q8NFH1; Q8NI12; Q8NI13; Q9BZF4; Q9UED6

Genbank Protein ID

AY008372; AF392444; AF491781; AF491782; AF491783; AF491784; AF491785; AF491786; AF515639; AF515640; AB014604; AC003093; AC004008; AC004016; AC004239; CH236948; CH236948; CH236948; CH236948; CH236948; CH236948; CH471073; CH471073; CH471073; CH471073; CH471073; CH471073; BC017731; AF323727

Genbank Nucleotide ID

AAG23400.1; AAL40657.1; AAM27386.1; AAM27387.1; AAM27388.1; AAM27389.1; AAM27390.1; AAM27391.1; AAM74165.1; AAM74166.1; BAA31679.2; AAB83939.1; AAC26986.2; EAL24240.1; EAL24241.1; EAL24242.1; EAL24243.1; EAL24244.1; EAL24245.1; EAW93816.1; EAW93817.1; EAW93818.1; EAW93819.1; EAW93820.1; EAW93821.1; AAH17731.1; AAG53408.1

Protein Name

Oxysterol-binding protein-related protein 3

Protein Synonyms/Alias

ORP-3; OSBP-related protein 3

Gene Name

OSBPL3

Gene Synonyms/Alias

KIAA0704; ORP3; OSBP3

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
55	TQEPPVQKGFLLKKR	ubiquitination	[1]
60	VQKGFLLKKRKWPLK	ubiquitination	[1]
511	NIGKDLSKVAMPVEL	ubiquitination	[1]
798	LEEAEIQKQRIEQLQ	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Sequence Annotation

DOMAIN 51 146 PH.
MOD_RES 16 16 Phosphoserine.
MOD_RES 34 34 Phosphoserine.
MOD_RES 251 251 Phosphoserine.
MOD_RES 304 304 Phosphoserine.
MOD_RES 372 372 Phosphoserine.
MOD_RES 410 410 Phosphoserine.
MOD_RES 437 437 Phosphoserine.

Keyword

Alternative splicing; Complete proteome; Lipid transport; Lipid-binding; Phosphoprotein; Polymorphism; Reference proteome; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

887 AA

Protein Sequence

MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 60
KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 120
EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 180
SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 240
QSMDVLHRTY SAPAINAIQV PKPFSGPVRL HSSNPNLSTL DFGEEKNYSD GSETSSEFSK 300
MQEDLCHIAH KVYFTLRSAF NIMSAEREKL KQLMEQDASS SPSAQVIGLK NALSSALAQN 360
TDLKERLRRI HAESLLLDSP AVAKSGDNLA EENSRDENRA LVHQLSNESR LSITDSLSEF 420
FDAQEVLLSP SSSENEISDD DSYVSDISDN LSLDNLSNDL DNERQTLGPV LDSGREAKSR 480
RRTCLPAPCP SSSNISLWNI LRNNIGKDLS KVAMPVELNE PLNTLQRLCE ELEYSELLDK 540
AAQIPSPLER MVYVAAFAIS AYASSYYRAG SKPFNPVLGE TYECIREDKG FQFFSEQVSH 600
HPPISACHAE SRNFVFWQDV RWKNKFWGKS MEIVPIGTTH VTLPVFGDHF EWNKVTSCIH 660
NILSGQRWIE HYGEIVIKNL HDDSCYCKVN FIKAKYWSTN AHEIEGTVFD RSGKAVHRLF 720
GKWHESIYCG GGSSSACVWR ANPMPKGYEQ YYSFTQFALE LNEMDPSSKS LLPPTDTRFR 780
PDQRFLEEGN LEEAEIQKQR IEQLQRERRR VLEENHVEHQ PRFFRKSDDD SWVSNGTYLE 840
LRKDLGFSKL DHPVLW 856

Gene Ontology

GO:0005829; C:cytosol; IDA:BHF-UCL.
GO:0031965; C:nuclear membrane; IDA:BHF-UCL.
GO:0097038; C:perinuclear endoplasmic reticulum; IDA:BHF-UCL.
GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO:0015485; F:cholesterol binding; IDA:BHF-UCL.
GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0006869; P:lipid transport; IEA:UniProtKB-KW.

Interpro

IPR000648; Oxysterol-bd.
IPR018494; Oxysterol-bd_CS.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.

Pfam

PF01237; Oxysterol_BP
PF00169; PH

SMART

SM00233; PH

PROSITE

PS01013; OSBP
PS50003; PH_DOMAIN

PRINTS