UniProt Accession

 VAT1_MOUSE; Q62465; Q8R3G0; Q8R3T8 

Genbank Protein ID

 AK034795; BC024586; BC025496; X95562 

Genbank Nucleotide ID

 BAC28833.1; AAH24586.1; AAH25496.1; CAA64807.1 

Protein Name

 Synaptic vesicle membrane protein VAT-1 homolog 

Protein Synonyms/Alias

  

Gene Name

 Vat1 

Gene Synonyms/Alias

 Vat-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
76	FGGYDKVKLQSRPAV	ubiquitination	[1]
263	TDYVDEIKKISPKGV	ubiquitination	[1]
268	EIKKISPKGVDIVMD	ubiquitination	[1]
308	ANLLTGPKRNLMAMA	ubiquitination	[1]
368	LYNQGHIKPRIDSVW	ubiquitination	[1]
379	DSVWPFEKVADAMKQ	acetylation	[2]
385	EKVADAMKQMQEKKN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 33 33 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion outer membrane; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0010637; P:negative regulation of mitochondrial fusion; ISS:UniProtKB. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom.
 IPR002364; Quin_OxRdtase/zeta-crystal_CS. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS01162; QOR_ZETA_CRYSTAL 

PRINTS