UniProt Accession

 AN32A_RAT; P49911 

Genbank Protein ID

 D32209 

Genbank Nucleotide ID

 BAA06908.1 

Protein Name

 Acidic leucine-rich nuclear phosphoprotein 32 family member A 

Protein Synonyms/Alias

 Leucine-rich acidic nuclear protein; LANP 

Gene Name

 Anp32a 

Gene Synonyms/Alias

 Lanp 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
5	***MEMDKRIYLELR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression (By similarity). 

Sequence Annotation

 REPEAT 18 41 LRR 1.
 REPEAT 43 64 LRR 2.
 REPEAT 65 87 LRR 3.
 REPEAT 89 110 LRR 4.
 DOMAIN 123 161 LRRCT.
 REGION 150 172 Necessary for tumor-suppressive function
 REGION 165 247 Interaction with E4F1 (By similarity).
 MOD_RES 15 15 Phosphothreonine (By similarity).
 MOD_RES 17 17 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Endoplasmic reticulum; Leucine-rich repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 247 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0008092; F:cytoskeletal protein binding; TAS:RGD.
 GO:0006913; P:nucleocytoplasmic transport; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003603; U2A'_phosphoprotein32A_C. 

Pfam

 PF12799; LRR_4 

SMART

 SM00446; LRRcap 

PROSITE

 PS51450; LRR 

PRINTS