CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007421
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-methyl-L-tryptophan oxidase 
Protein Synonyms/Alias
 MTOX 
Gene Name
 solA 
Gene Synonyms/Alias
 b1059; JW1046 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
59HAYGEGEKYVPLVLRacetylation[1]
194ADGEYQAKKAIVCAGacetylation[1]
234GRYSVKNKFPAFTGEacetylation[1]
357AADFAQDKKSDFDLTacetylation[1]
357AADFAQDKKSDFDLTpupylation[2]
358ADFAQDKKSDFDLTPacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222] 
Functional Description
 Catalyzes the oxidative demethylation of N-methyl-L- tryptophan. Can also use other N-methyl amino acids, including sarcosine, which, however, is a poor substrate. 
Sequence Annotation
 NP_BIND 4 34 FAD (Potential).
 MOD_RES 308 308 S-8alpha-FAD cysteine.  
Keyword
 3D-structure; Complete proteome; FAD; Flavoprotein; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 372 AA 
Protein Sequence
MKYDLIIIGS GSVGAAAGYY ATRAGLNVLM TDAHMPPHQH GSHHGDTRLI RHAYGEGEKY 60
VPLVLRAQTL WDELSRHNEE DPIFVRSGVI NLGPADSTFL ANVAHSAEQW QLNVEKLDAQ 120
GIMARWPEIR VPDNYIGLFE TDSGFLRSEL AIKTWIQLAK EAGCAQLFNC PVTAIRHDDD 180
GVTIETADGE YQAKKAIVCA GTWVKDLLPE LPVQPVRKVF AWYQADGRYS VKNKFPAFTG 240
ELPNGDQYYG FPAENDALKI GKHNGGQVIH SADERVPFAE VASDGSEAFP FLRNVLPGIG 300
CCLYGAACTY DNSPDEDFII DTLPGHDNTL LITGLSGHGF KFASVLGEIA ADFAQDKKSD 360
FDLTPFRLSR FQ 372 
Gene Ontology
 GO:0050660; F:flavin adenine dinucleotide binding; IDA:EcoCyc.
 GO:0050131; F:N-methyl-L-amino-acid oxidase activity; IDA:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 
Interpro
 IPR006076; FAD-dep_OxRdtase.
 IPR023493; Me_Trp_Oxase_MTOX. 
Pfam
 PF01266; DAO 
SMART
  
PROSITE
  
PRINTS