| Tag | Content |
|---|
| CPLM ID | CPLM-006908 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitofusin FZO1 |
Protein Synonyms/Alias | Transmembrane GTPase FZO1 |
Gene Name | FZO1 |
Gene Synonyms/Alias | YBR179C; YBR1241 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 79 | SLRSSNSKAHLISSQ | ubiquitination | [1] | | 209 | ALCNSLLKQRLLPED | ubiquitination | [1] | | 370 | KLMFFVVKKFDKIRD | ubiquitination | [1] | | 398 | DLSPETYKRAADFVH | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondrial morphology, which is balanced between fusion and fission, mediated by FZO1 and DNM1, respectively. Functions antagonistically with DNM1. May act by forming membrane contact sites that mediate mitochondrial fusion. Mitochondrial fusion promotes also increased lifespan. |
Sequence Annotation | NP_BIND 194 201 GTP (Probable).
NP_BIND 313 317 GTP (Probable).
NP_BIND 370 373 GTP (Probable).
REGION 91 190 HRN.
REGION 484 547 HR1.
REGION 630 843 Required for interaction with UGO1.
REGION 769 831 HR2.
CROSSLNK 398 398 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 464 464 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Coiled coil; Complete proteome; GTP-binding; Hydrolase; Isopeptide bond; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 855 AA |
Protein Sequence | MSEGKQQFKD SNKPHKDSTD QDDDAATIVP QTLTYSRNEG HFLGSNFHGV TDDRTTLFDG 60
EEGRREDDLL PSLRSSNSKA HLISSQLSQW NYNNNRVLLK RSILKTQAFM DQLQEENNIR 120
PIFIAANDER EKLHVLQLNI KLDGQYNTKE KNGFNIEKKA LSKLFHSQIV SVTNHLNALK 180
KRVDDVSSKV FITGDVNTGK SALCNSLLKQ RLLPEDQLPC TNVFSEILEA RENDGIEEVH 240
AIPLNIAPTL KEAIDMYSIQ NPKTYEIHTL KELPDLVPQN GKYALLKIYI KDDKRPASTS 300
LLRNGTVDIS LIDSPGLNMD SLQTAEVMSR QEEIDLVIFV VNAENQLTLS AKEFISLASR 360
EKKLMFFVVK KFDKIRDKQR CKELILKQIR DLSPETYKRA ADFVHFVSKN GDELPHYHNE 420
NDNEDHGDRK PDDDPYSSSD PDPDFDSLED SLRNFVLKKR SLSKLLPAKT YLSKLLSDII 480
MISKSNMKMY SEEEIKINEQ LETLRPEILS ARAKCNDLTT SVDQMAEQTI TMTYNNTKEA 540
LLNALDVPLH EYPKYQGLGQ IYDFIFSTEA FIANQIDESI GSSELFAKQK TDLLVKKIYE 600
IGKNELGDDF MCERVFRSEL MFRKRKHLIG KRLKVSLSIT DLFAPTWKGF LSYLSWQKPV 660
TAPLPDIEGQ TNEGQIGLMK YLGLKNYPLT QYWSRPSLLF TSKIPTLTLY FLGSTKVVGN 720
IILNGIKLSS WSSLKKLSVP VIVVGSLLGL TYLIHDLPRA LPMNLSIKYK RKLQELDYIH 780
LNAQRTSNEV RDVLRVPTRE ILRSCEIIMD KKQITKKELE NKKESNLLSI KFFQSLYEGT 840
VAQKLMVEEI NLDID 855 |
Gene Ontology | GO:0031307; C:integral to mitochondrial outer membrane; IDA:SGD. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IDA:SGD. GO:0042803; F:protein homodimerization activity; IDA:SGD. GO:0008053; P:mitochondrial fusion; IMP:SGD. GO:0051646; P:mitochondrion localization; IGI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |