UniProt Accession

 ARPC3_MOUSE; Q9JM76; Q3TAT0 

Genbank Protein ID

 AB038243; AK003485; AK005437; AK171651; BC013618; BC054440 

Genbank Nucleotide ID

 BAA90788.1; BAB22813.1; BAB24031.1; BAE42588.1; AAH13618.1; AAH54440.1 

Protein Name

 Actin-related protein 2/3 complex subunit 3 

Protein Synonyms/Alias

 Arp2/3 complex 21 kDa subunit; p21-ARC 

Gene Name

 Arpc3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
14	SLMDPDTKLIGNMAL	ubiquitination	[1]
37	GPAPRETKDTDIVDE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). 

Sequence Annotation

 MOD_RES 47 47 Phosphotyrosine.
 MOD_RES 56 56 N6-acetyllysine (By similarity).
 MOD_RES 61 61 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0005885; C:Arp2/3 protein complex; TAS:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro. 

Interpro

 IPR007204; ARP2/3_p21-Arc. 

Pfam

 PF04062; P21-Arc 

SMART

  

PROSITE

  

PRINTS