UniProt Accession

 RAP2A_MOUSE; Q80ZJ1; Q3USK1; Q7TSK4; Q810A2; Q9D3D5 

Genbank Protein ID

 AK018024; AK140318; BC043066; BC049084; BC053003 

Genbank Nucleotide ID

 BAB31042.1; BAE24330.1; AAH43066.2; AAH49084.2; AAH53003.1 

Protein Name

 Ras-related protein Rap-2a 

Protein Synonyms/Alias

  

Gene Name

 Rap2a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
108	IRVKRYEKVPVILVG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 116 119 GTP (By similarity).
 MOTIF 32 40 Effector region (By similarity).
 MOD_RES 180 180 Cysteine methyl ester (By similarity).
 LIPID 180 180 S-farnesyl cysteine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Endosome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Prenylation; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 183 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
 GO:0034613; P:cellular protein localization; ISS:UniProtKB.
 GO:0045184; P:establishment of protein localization; ISO:MGI.
 GO:0030336; P:negative regulation of cell migration; IDA:MGI.
 GO:0031954; P:positive regulation of protein autophosphorylation; IDA:MGI.
 GO:0032486; P:Rap protein signal transduction; IDA:UniProtKB.
 GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.
 GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.