CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021553
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-2-hydroxyglutarate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 Duranin 
Gene Name
 L2HGDH 
Gene Synonyms/Alias
 C14orf160 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
104IHSGIYYKPESLKAKacetylation[1]
155RLQALYEKGLQNGVPacetylation[1]
155RLQALYEKGLQNGVPubiquitination[2]
226VKGIEMAKESPSRSIubiquitination[2]
246PIVIKNTKGEEIRCQubiquitination[2]
297PEKCYLVKGNIYPVPubiquitination[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 MOD_RES 104 104 N6-acetyllysine.
 MOD_RES 155 155 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Disease mutation; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 463 AA 
Protein Sequence
MVPALRYLVG ACGRARGLFA GGSPGACGFA SGRPRPLCGG SRSASTSSFD IVIVGGGIVG 60
LASARALILR HPSLSIGVLE KEKDLAVHQT GHNSGVIHSG IYYKPESLKA KLCVQGAALL 120
YEYCQQKGIS YKQCGKLIVA VEQEEIPRLQ ALYEKGLQNG VPGLRLIQQE DIKKKEPYCR 180
GLMAIDCPHT GIVDYRQVAL SFAQDFQEAG GSVLTNFEVK GIEMAKESPS RSIDGMQYPI 240
VIKNTKGEEI RCQYVVTCAG LYSDRISELS GCTPDPRIVP FRGDYLLLKP EKCYLVKGNI 300
YPVPDSRFPF LGVHFTPRMD GSIWLGPNAV LAFKREGYRP FDFSATDVMD IIINSGLIKL 360
ASQNFSYGVT EMYKACFLGA TVKYLQKFIP EITISDILRG PAGVRAQALD RDGNLVEDFV 420
FDAGVGDIGN RILHVRNAPS PAATSSIAIS GMIADEVQQR FEL 463 
Gene Ontology
 GO:0031305; C:integral to mitochondrial inner membrane; NAS:HGNC.
 GO:0047545; F:2-hydroxyglutarate dehydrogenase activity; IDA:HGNC.
 GO:0006103; P:2-oxoglutarate metabolic process; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; IDA:HGNC. 
Interpro
 IPR006076; FAD-dep_OxRdtase. 
Pfam
 PF01266; DAO 
SMART
  
PROSITE
  
PRINTS