CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018455
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Long-chain fatty acid transport protein 4 
Protein Synonyms/Alias
 FATP-4; Fatty acid transport protein 4; Solute carrier family 27 member 4 
Gene Name
 Slc27a4 
Gene Synonyms/Alias
 Acsvl4; Fatp4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
595LHKTGTFKFQKTELRacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. 
Sequence Annotation
 NP_BIND 243 254 AMP (Potential).  
Keyword
 Complete proteome; Fatty acid metabolism; Ligase; Lipid metabolism; Lipid transport; Membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 643 AA 
Protein Sequence
MLLGASLVGA LLFSKLVLKL PWTQVGFSLL LLYLGSGGWR FIRVFIKTVR RDIFGGMVLL 60
KVKTKVRRYL QERKTVPLLF ASMVQRHPDK TALIFEGTDT HWTFRQLDEY SSSVANFLQA 120
RGLASGNVVA LFMENRNEFV GLWLGMAKLG VEAALINTNL RRDALRHCLD TSKARALIFG 180
SEMASAICEI HASLEPTLSL FCSGSWEPST VPVSTEHLDP LLEDAPKHLP SHPDKGFTDK 240
LFYIYTSGTT GLPKAAIVVH SRYYRMASLV YYGFRMRPDD IVYDCLPLYH SAGNIVGIGQ 300
CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE SRHKVRMALG 360
NGLRQSIWTD FSSRFHIPQV AEFYGATECN CSLGNFDSRV GACGFNSRIL SFVYPIRLVR 420
VNEDTMELIR GPDGVCIPCQ PGQPGQLVGR IIQQDPLRRF DGYLNQGANN KKIANDVFKK 480
GDQAYLTGDV LVMDELGYLY FRDRTGDTFR WKGENVSTTE VEGTLSRLLH MADVAVYGVE 540
VPGTEGRAGM AAVASPISNC DLESFAQTLK KELPLYARPI FLRFLPELHK TGTFKFQKTE 600
LRKEGFDPSV VKDPLFYLDA RKGCYVALDQ EAYTRIQAGE EKL 643 
Gene Ontology
 GO:0031526; C:brush border membrane; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005902; C:microvillus; IDA:MGI.
 GO:0004467; F:long-chain fatty acid-CoA ligase activity; IDA:MGI.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IDA:MGI.
 GO:0044539; P:long-chain fatty acid import; IEA:Compara.
 GO:0015909; P:long-chain fatty acid transport; IMP:MGI.
 GO:0001579; P:medium-chain fatty acid transport; IDA:MGI.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0042760; P:very long-chain fatty acid catabolic process; IDA:MGI. 
Interpro
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR022272; Lipocalin_CS. 
Pfam
 PF00501; AMP-binding 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS