CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021033
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leukotriene-B4 omega-hydroxylase 3 
Protein Synonyms/Alias
 Cyp4f-14; Cytochrome P450 4F14; Cytochrome P450-LTB-omega; Leukotriene-B4 20-monooxygenase 3 
Gene Name
 Cyp4f14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
75TPTEQGLKELTRLVGubiquitination[1]
143LLVSAGDKWSRHRRMubiquitination[1]
161AFHFNILKPYVKIFNubiquitination[1]
177STNIMHAKWQRLISDubiquitination[1]
258PDGMRFRKACNVVHEubiquitination[1]
288QGLDDFLKSKAKSKTubiquitination[1]
290LDDFLKSKAKSKTLDubiquitination[1]
294LKSKAKSKTLDFIDVubiquitination[1]
306IDVLLLSKDEDGKELubiquitination[1]
451RFDPENIKDSSPLAFubiquitination[1]
496FRLLPDDKEPRRQPEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4 (By similarity). 
Sequence Annotation
 METAL 468 468 Iron (heme axial ligand) (By similarity).
 BINDING 328 328 Heme (covalent; via 1 link) (By  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 524 AA 
Protein Sequence
MSQLSLSWLG LGPEVAFPWK TLLLLGASWI LARILIQIYA AYRNYRHLHG FPQPPKRNWL 60
MGHVGMVTPT EQGLKELTRL VGTYPQGFLM WIGPMVPVIT LCHSDIVRSI LNASAAVALK 120
DVIFYSILKP WLGDGLLVSA GDKWSRHRRM LTPAFHFNIL KPYVKIFNDS TNIMHAKWQR 180
LISDGSARLD MFEHVSLMTL DSLQKCVFSF DSNCQEKSSE YIAAILELSA LVAKRHQQPL 240
MFMDLLYNLT PDGMRFRKAC NVVHEFTDAV IRERHRTLPD QGLDDFLKSK AKSKTLDFID 300
VLLLSKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWI LYNLARHPEY QERCRQEVQE 360
LLRGREPEEI EWDDLAQLPF LTMCIKESLR LHPPVTVISR CCTQDILLPD GRTIPKGIIC 420
LISIFGIHHN PSVWPDPEVY DPFRFDPENI KDSSPLAFIP FSAGPRNCIG QTFAMSEMKV 480
ALALTLLRFR LLPDDKEPRR QPELILRAEG GLWLRVEPLS AGAH 524 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0052871; F:alpha-tocopherol omega-hydroxylase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0050051; F:leukotriene-B4 20-monooxygenase activity; IEA:EC.
 GO:0036101; P:leukotriene B4 catabolic process; IEA:GOC. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.