UniProt Accession

 KDSA_ECOLI; P0A715; P17579 

Genbank Protein ID

 X05552; U18555; U00096; AP009048 

Genbank Nucleotide ID

 CAA29067.1; AAC43441.1; AAC74299.1; BAA36073.1 

Protein Name

 2-dehydro-3-deoxyphosphooctonate aldolase 

Protein Synonyms/Alias

 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase 

Gene Name

 kdsA 

Gene Synonyms/Alias

 b1215; JW1206 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
47	HYVTVTQKLGIPYVF	acetylation	[1]
55	LGIPYVFKASFDKAN	acetylation	[1]
60	VFKASFDKANRSSIH	acetylation	[1, 2, 3]
79	PGLEEGMKIFQELKQ	acetylation	[1, 3]
79	PGLEEGMKIFQELKQ	pupylation	[4]
85	MKIFQELKQTFGVKI	acetylation	[1]
130	DLVEAMAKTGAVINV	acetylation	[1]
138	TGAVINVKKPQFVSP	acetylation	[1]
139	GAVINVKKPQFVSPG	acetylation	[1]
154	QMGNIVDKFKEGGNE	acetylation	[1]
156	GNIVDKFKEGGNEKV	acetylation	[1]
162	FKEGGNEKVILCDRG	acetylation	[1]
189	LGFSIMKKVSGNSPV	acetylation	[1]
248	HPDPEHAKCDGPSAL	acetylation	[1]
259	PSALPLAKLEPFLKQ	acetylation	[1]
265	AKLEPFLKQMKAIDD	acetylation	[1]
268	EPFLKQMKAIDDLVK	acetylation	[1]
275	KAIDDLVKGFEELDT	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508]
 [3] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [4] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222] 

Functional Description

 Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Lipopolysaccharide biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0008676; F:3-deoxy-8-phosphooctulonate synthase activity; IDA:EcoCyc.
 GO:0019294; P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IEA:HAMAP. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR006218; DAHP1/KDSA.
 IPR006269; KDO8P_synthase. 

Pfam

 PF00793; DAHP_synth_1 

SMART

  

PROSITE

  

PRINTS