UniProt Accession

 MO4L1_MOUSE; P60762; Q8BNY9; Q99MQ0 

Genbank Protein ID

 AF319620; AF319621; AK079115; AK016414; BC003894; BC017619; BC083118; BC085103 

Genbank Nucleotide ID

 AAK07406.1; AAK07407.1; BAC37546.1; BAB30219.1; AAH03894.1; AAH17619.1; AAH83118.1; AAH85103.1 

Protein Name

 Mortality factor 4-like protein 1 

Protein Synonyms/Alias

 MORF-related gene 15 protein; Testis-expressed gene 189 protein; Transcription factor-like protein MRG15 

Gene Name

 Morf4l1 

Gene Synonyms/Alias

 Mrg15; Tex189 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
103	VPESRVLKYVDTNLQ	ubiquitination	[1]
111	YVDTNLQKQRELQKA	ubiquitination	[1]
117	QKQRELQKANQEQYA	ubiquitination	[1]
127	QEQYAEGKMRGAAPG	ubiquitination	[1]
143	KTSGLQQKNVEVKTK	ubiquitination	[1]
226	QLFYLPAKKNVDSIL	ubiquitination	[1]
227	LFYLPAKKNVDSILE	ubiquitination	[1]
240	LEDYANYKKSRGNTD	ubiquitination	[1]
249	SRGNTDNKEYAVNEV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity). 

Sequence Annotation

 DOMAIN 191 362 MRG.
 REGION 26 62 Interaction with KAT8 (By similarity).
 REGION 133 266 Sufficient for interaction with SIN3A (By
 REGION 164 230 Interaction with RB1-1 (By similarity).
 REGION 188 342 Sufficient for interaction with PHF12 (By
 REGION 323 344 Interaction with RB1-2 (By similarity).
 MOTIF 135 146 Nuclear localization signal (Potential).
 MOD_RES 143 143 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Chromatin regulator; Complete proteome; DNA damage; DNA recombination; DNA repair; Growth regulation; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
 GO:0016580; C:Sin3 complex; ISS:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0008283; P:cell proliferation; IMP:MGI.
 GO:0006338; P:chromatin remodeling; TAS:MGI.
 GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
 GO:0016575; P:histone deacetylation; ISS:UniProtKB.
 GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
 GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016197; Chromodomain-like.
 IPR017398; EAF3/MRG15.
 IPR008676; MRG.
 IPR026541; MRG_dom.
 IPR025995; Tudor-knot. 

Pfam

 PF05712; MRG
 PF11717; Tudor-knot 

SMART

  

PROSITE

 PS51640; MRG 

PRINTS