CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004715
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein G(o) subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 Gnao1 
Gene Synonyms/Alias
 Gna0; Gnao 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
21ERSKAIEKNLKEDGIubiquitination[1]
24KAIEKNLKEDGISAAubiquitination[1]
32EDGISAAKDVKLLLLubiquitination[1]
35ISAAKDVKLLLLGAGubiquitination[1]
54STIVKQMKIIHEDGFubiquitination[1]
278KKDLFGEKIKKSPLTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Stimulated by RGS14. The G(o) protein function is not clear. 
Sequence Annotation
 NP_BIND 40 47 GTP (By similarity).
 NP_BIND 176 182 GTP (By similarity).
 NP_BIND 201 205 GTP (By similarity).
 NP_BIND 270 273 GTP (By similarity).
 METAL 47 47 Magnesium (By similarity).
 METAL 182 182 Magnesium (By similarity).
 BINDING 326 326 GTP; via amide nitrogen (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).
 LIPID 3 3 S-palmitoyl cysteine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Magnesium; Metal-binding; Myristate; Nucleotide-binding; Palmitate; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MGCTLSAEER AALERSKAIE KNLKEDGISA AKDVKLLLLG AGESGKSTIV KQMKIIHEDG 60
FSGEDVKQYK PVVYSNTIQS LAAIVRAMDT LGVEYGDKER KTDSKMVCDV VSRMEDTEPF 120
SAELLSAMMR LWGDSGIQEC FNRSREYQLN DSAKYYLDSL DRIGAGDYQP TEQDILRTRV 180
KTTGIVETHF TFKNLHFRLF DVGGQRSERK KWIHCFEDVT AIIFCVALSG YDQVLHEDET 240
TNRMHESLML FDSICNNKFF IDTSIILFLN KKDLFGEKIK KSPLTICFPE YPGSNTYEDA 300
AAYIQTQFES KNRSPNKEIY CHMTCATDTN NIQVVFDAVT DIIIANNLRG CGLY 354 
Gene Ontology
 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0031821; F:G-protein coupled serotonin receptor binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IMP:MGI.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0007568; P:aging; IEA:Compara.
 GO:0007212; P:dopamine receptor signaling pathway; IMP:MGI.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0051926; P:negative regulation of calcium ion transport; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0043547; P:positive regulation of GTPase activity; IEA:Compara.
 GO:0008016; P:regulation of heart contraction; IMP:MGI.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0043278; P:response to morphine; IEA:Compara. 
Interpro
 IPR001408; Gprotein_alpha_I.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00503; G-alpha 
SMART
 SM00275; G_alpha 
PROSITE
  
PRINTS
 PR00318; GPROTEINA.
 PR00441; GPROTEINAI.