CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032006
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-zipper-like transcriptional regulator 1 
Protein Synonyms/Alias
 cDNA FLJ53345, highly similar to Leucine-zipper-like transcriptional regulator1 
Gene Name
 LZTR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
147TGQWTEWKIEGRLPVubiquitination[1]
242NLFQFEFKDKTWTRIubiquitination[1]
356DFGTTSAKQPTQPASubiquitination[1, 2, 3, 4]
407FQFSCYPKCTLHEDYubiquitination[1]
465ARERLAQKLEQEAAPubiquitination[1, 2, 3, 4]
596FNQVIMMKEFERLSSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kelch repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 821 AA 
Protein Sequence
MAGPGSTGGQ IGAAALAGGA RSKVAPSVDF DHSCSDSVEY LTLNFGPFET VHRWRRLPPC 60
DEFVGARRSK HTVVAYKDAI YVFGGDNGAF TTGTPPAPRY HHSAVVYGSS MFVFGGYTGD 120
IYSNSNLKNK NDLFEYKFAT GQWTEWKIEG RLPVARSAHG ATVYSDKLWI FAGYDGNARL 180
NDMWTIGLQD RELTCWEEVA QSGEIPPSCC NFPVAVCRDK MFVFSGQSGA KITNNLFQFE 240
FKDKTWTRIP TEHLLRGSPP PPQRRYGHTM VAFDRHLYVF GGAADNTLPN ELHCYDVDFQ 300
TWEVVQPSSD SEVGGAEVPE RACASEEVPT LTYEERVGFK KSRDVFGLDF GTTSAKQPTQ 360
PASELPSGRL FHAAAVISDA MYIFGGTVDN NIRSGEMYRF QFSCYPKCTL HEDYGRLWES 420
RQFCDVEFVL GEKEECVQGH VAIVTARSRW LRRKITQARE RLAQKLEQEA APVPREAPGV 480
AAGGARPPLL HVAIREAEAR PFEVLMQFLY TDKIKYPRKG HVEDVLLIMD VYKLALSFQL 540
CRLEQLCRQY IEASVDLQNV LVVCESAARL QLSQLKEHCL NFVVKESHFN QVIMMKEFER 600
LSSPLIVEIV RRKQQPPPRT PLDQPVDIGT SLIQDMKAYL EGAGAEFCDI TLLLDGHPRP 660
AHKAILAARS SYFEAMFRSF MPEDGQVNIS IGEMVPSRQA FESMLRYIYY GEVNMPPEDS 720
LYLFAAPYYY GFYNNRLQAY CKQNLEMNVT VQNVLQILEA ADKTQALDMK RHCLHIIVHQ 780
FTKVSKLPTL RSLSQQLLLD IIDSLASHIS DKQCAELGAD I 821 
Gene Ontology
  
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 
Pfam
 PF00651; BTB
 PF01344; Kelch_1 
SMART
 SM00225; BTB 
PROSITE
 PS50097; BTB 
PRINTS