CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017438
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD and tetratricopeptide repeats protein 1 
Protein Synonyms/Alias
  
Gene Name
 WDTC1 
Gene Synonyms/Alias
 KIAA1037 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
169YDLRENSKHSEVLIDubiquitination[1]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
 REPEAT 45 84 WD 1.
 REPEAT 88 129 WD 2.
 REPEAT 132 172 WD 3.
 REPEAT 182 222 WD 4.
 REPEAT 265 305 WD 5.
 REPEAT 362 395 TPR 1.
 REPEAT 397 432 TPR 2.
 REPEAT 535 575 WD 6.
 REPEAT 578 617 WD 7.
 MOD_RES 511 511 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat; TPR repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 60
LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 120
LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY 180
CGQLVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK 240
PLPDGAAQYY VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK 300
QRPYTFLLPR KCHSSGEVQN GKMSTNGVSN GVSNGLHLHS NGFRLPESRG HVSPQVELPP 360
YLERVKQQAN EAFACQQWTQ AIQLYSKAVQ RAPHNAMLYG NRAAAYMKRK WDGDHYDALR 420
DCLKAISLNP CHLKAHFRLA RCLFELKYVA EALECLDDFK GKFPEQAHSS ACDALGRDIT 480
AALFSKNDGE EKKGPGGGAP VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI 540
KEANFFGSNA QYIVSGSDDG SFFIWEKETT NLVRVLQGDE SIVNCLQPHP SYCFLATSGI 600
DPVVRLWNPR PESEDLTGRV VEDMEGASQA NQRRMNADPL EVMLLNMGYR ITGLSSGGAG 660
ASDDEDSSEG QVQCRPS 677 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004857; F:enzyme inhibitor activity; IEA:Compara.
 GO:0055082; P:cellular chemical homeostasis; IEA:Compara.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0006006; P:glucose metabolic process; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0008361; P:regulation of cell size; IEA:Compara. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF07719; TPR_2
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS