UniProt Accession

 U119B_HUMAN; A6NIH7 

Genbank Protein ID

 AK126367; AC069234; CH471054; BC004815 

Genbank Nucleotide ID

 EAW98216.1 

Protein Name

 Protein unc-119 homolog B 

Protein Synonyms/Alias

  

Gene Name

 UNC119B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	PGGLVAGKEEKKKAG	acetylation	[1, 2, 3, 4]
86	VTENYLCKPEDNIYS	ubiquitination	[5]
242	NKLIMHNKADYAYNG	ubiquitination	[5]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. 

Sequence Annotation

 BINDING 142 142 Lipid (By similarity).
 MOD_RES 24 24 N6-acetyllysine.  

Keyword

 Acetylation; Cell projection; Cilium; Cilium biogenesis/degradation; Complete proteome; Lipid-binding; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 251 AA 

Protein Sequence

Gene Ontology

 GO:0035869; C:ciliary transition zone; IDA:UniProtKB.
 GO:0008289; F:lipid binding; IDA:UniProtKB.
 GO:0060271; P:cilium morphogenesis; IMP:UniProtKB.
 GO:0042953; P:lipoprotein transport; IDA:UniProtKB. 

Interpro

 IPR008015; GMP_PDE_delta.
 IPR014756; Ig_E-set. 

Pfam

 PF05351; GMP_PDE_delta 

SMART

  

PROSITE

  

PRINTS